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@article{Thomas:2011:10.1063/1.3661156,
author = {Thomas, P and Straube, AV and Grima, R},
doi = {10.1063/1.3661156},
journal = {Journal of Chemical Physics},
title = {Communication: Limitations of the stochastic quasi-steady-state approximation in open biochemical reaction networks},
url = {http://dx.doi.org/10.1063/1.3661156},
volume = {135},
year = {2011}
}
TY - JOUR
AB - It is commonly believed that, whenever timescale separation holds, the predictions of reduced chemical master equations obtained using the stochastic quasi-steady-state approximation are in very good agreement with the predictions of the full master equations. We use the linear noise approximation to obtain a simple formula for the relative error between the predictions of the two master equations for the Michaelis-Menten reaction with substrate input. The reduced approach is predicted to overestimate the variance of the substrate concentration fluctuations by as much as 30%. The theoretical results are validated by stochastic simulations using experimental parameter values for enzymes involved in proteolysis, gluconeogenesis, and fermentation.
AU - Thomas,P
AU - Straube,AV
AU - Grima,R
DO - 10.1063/1.3661156
PY - 2011///
SN - 1089-7690
TI - Communication: Limitations of the stochastic quasi-steady-state approximation in open biochemical reaction networks
T2 - Journal of Chemical Physics
UR - http://dx.doi.org/10.1063/1.3661156
UR - http://hdl.handle.net/10044/1/40994
VL - 135
ER -