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@article{Strelkowa:2010:10.1098/rsif.2009.0487,
author = {Strelkowa, N and Barahona, M},
doi = {10.1098/rsif.2009.0487},
journal = {JOURNAL OF THE ROYAL SOCIETY INTERFACE},
pages = {(1071--1082)--(1071--1082)},
title = {Switchable genetic oscillator operating in quasi-stable mode},
url = {http://dx.doi.org/10.1098/rsif.2009.0487},
volume = {7},
year = {2010}
}
TY - JOUR
AB - Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, these attractors may not fully explain the observed behaviour in transient and stochastic environments such as the cell. We show here that even repressilators possess quasi-stable, travelling wave periodic solutions that are reachable, long-lived and robust to parameter changes. These solutions underlie the sustained oscillations observed in even rings in the stochastic regime, even if these circuits are expected to behave as switches. The existence of such solutions can also be exploited for control purposes: operation of the system around the quasi-stable orbit allows us to turn on and off the oscillations reliably and on demand. We illustrate these ideas with a simple protocol based on optical interference that can induce oscillations robustly both in the stochastic and deterministic regimes.
AU - Strelkowa,N
AU - Barahona,M
DO - 10.1098/rsif.2009.0487
EP - 1082
PY - 2010///
SN - 1742-5689
SP - 1071
TI - Switchable genetic oscillator operating in quasi-stable mode
T2 - JOURNAL OF THE ROYAL SOCIETY INTERFACE
UR - http://dx.doi.org/10.1098/rsif.2009.0487
UR - http://hdl.handle.net/10044/1/10371
VL - 7
ER -