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@article{Yaliraki:2007:10.1098/rsta.2007.0015,
author = {Yaliraki, SN and Barahona, M},
doi = {10.1098/rsta.2007.0015},
journal = {PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES},
pages = {(2921--2934)--(2921--2934)},
title = {Chemistry across scales: from molecules to cells},
url = {http://dx.doi.org/10.1098/rsta.2007.0015},
volume = {365},
year = {2007}
}
TY - JOUR
AB - Many important biological functions are strongly dependent on specific chemical interactions. Modelling how the physicochemical molecular details emerge at much larger scales is an active area of research, currently pursued with a variety of methods. We describe a series of theoretical and computational approaches that aim to derive bottom-up descriptions that capture the specificity that ensues from atomistic detail by extracting relevant features at the different scales. The multiscale models integrate the descriptions at different length and time scales by exploiting the idea of mechanical responses. The methodologies bring together concepts and tools developed in seemingly unrelated areas of mathematics such as algebraic geometry, model reduction, structural graph theory and non-convex optimization. We showcase the applicability of the framework with examples from protein engineering and enzyme catalysis, protein assembly, and with the description of lipid bilayers at different scales. Many challenges remain as it is clear that no single methodology will answer all questions in such multidimensional complex problems.
AU - Yaliraki,SN
AU - Barahona,M
DO - 10.1098/rsta.2007.0015
EP - 2934
PY - 2007///
SN - 1364-503X
SP - 2921
TI - Chemistry across scales: from molecules to cells
T2 - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
UR - http://dx.doi.org/10.1098/rsta.2007.0015
VL - 365
ER -