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@article{Prole:2020:10.1074/jbc.REV120.015101,
author = {Prole, DL and Chinnery, PF and Jones, NS},
doi = {10.1074/jbc.REV120.015101},
journal = {Journal of Biological Chemistry},
pages = {17588--17601},
title = {Visualizing, quantifying, and manipulating mitochondrial DNA in vivo},
url = {http://dx.doi.org/10.1074/jbc.REV120.015101},
volume = {295},
year = {2020}
}
TY - JOUR
AB - Mitochondrial DNA (mtDNA) encodes proteins and RNAs that support the functions of mitochondria and thereby numerous physiological processes. Mutations of mtDNA can cause mitochondrial diseases and are implicated in ageing. The mtDNA within cells is organized into nucleoids within the mitochondrial matrix, but how mtDNA nucleoids are formed and regulated within cells remains incompletely resolved. Visualization of mtDNA within cells is a powerful means by which mechanistic insight can be gained. Manipulation of the amount, and sequence of, mtDNA within cells is important experimentally and for developing therapeutic interventions to treat mitochondrial disease. This review details recent developments and opportunities for improvements in the experimental tools and techniques that can be used to visualize, quantify and manipulate the properties of mtDNA within cells.
AU - Prole,DL
AU - Chinnery,PF
AU - Jones,NS
DO - 10.1074/jbc.REV120.015101
EP - 17601
PY - 2020///
SN - 0021-9258
SP - 17588
TI - Visualizing, quantifying, and manipulating mitochondrial DNA in vivo
T2 - Journal of Biological Chemistry
UR - http://dx.doi.org/10.1074/jbc.REV120.015101
UR - https://www.ncbi.nlm.nih.gov/pubmed/33060202
UR - https://www.jbc.org/article/S0021-9258(17)50642-0/fulltext
UR - http://hdl.handle.net/10044/1/84834
VL - 295
ER -