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@article{Kidher:2014:10.1186/s13019-014-0193-6,
author = {Kidher, E and Cheng, Z and Jarral, OA and O'Regan, DP and Xu, XY and Athanasiou, T},
doi = {10.1186/s13019-014-0193-6},
journal = {Journal of Cardiothoracic Surgery},
title = {In-vivo assessment of the morphology and hemodynamic functions of the BioValsalva (TM) composite valve-conduit graft using cardiac magnetic resonance imaging and computational modelling technology},
url = {http://dx.doi.org/10.1186/s13019-014-0193-6},
volume = {9},
year = {2014}
}

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TY  - JOUR
AB  - Background: The evaluation of any new cardiac valvular prosthesis should go beyond the classical morbidityand mortality rates and involve hemodynamic assessment. As a proof of concept, the objective of this study wasto characterise for the first time the hemodynamics and the blood flow profiles at the aortic root in patientsimplanted with BioValsalva™ composite valve-conduit using comprehensive MRI and computer technologies.Methods: Four male patients implanted with BioValsalva™ and 2 age-matched normal controls (NC) underwent cardiacmagnetic resonance imaging (MRI). Phase-contrast imaging with velocity-mapping in 3 orthogonal directions wasperformed at the level of the aortic root and descending thoracic aorta. Computational fluid dynamic (CFD) simulationswere performed for all the subjects with patient-specific flow information derived from phase-contrast MR data.Results: The maximum and mean flow rates throughout the cardiac cycle at the aortic root level were very comparablebetween NC and BioValsalva™ patients (541 ± 199 vs. 567 ± 75 ml/s) and (95 ± 46 vs. 96 ± 10 ml/s), respectively.The maximum velocity (cm/s) was higher in patients (314 ± 49 vs. 223 ± 20; P = 0.06) due to relatively smaller effectiveorifice area (EOA), 2.99 ± 0.47 vs. 4.40 ± 0.24 cm2 (P = 0.06), however, the BioValsalva™ EOA was comparable to otherreported prosthesis. The cross-sectional area and maximum diameter at the root were comparable between the twogroups. BioValsalva™ conduit was stiffer than the native aortic wall, compliance (mm2 • mmHg−1 • 10−3) values were(12.6 ± 4.2 vs 25.3 ± 0.4.; P = 0.06). The maximum time-averaged wall shear stress (Pa), at the ascending aorta wasequivalent between the two groups, 17.17 ± 2.7 (NC) vs. 17.33 ± 4.7 (BioValsalva™ ). Flow streamlines at the root andascending aorta were also similar between the two groups apa
AU  - Kidher,E
AU  - Cheng,Z
AU  - Jarral,OA
AU  - O'Regan,DP
AU  - Xu,XY
AU  - Athanasiou,T
DO  - 10.1186/s13019-014-0193-6
PY  - 2014///
SN  - 1749-8090
TI  - In-vivo assessment of the morphology and hemodynamic functions of the BioValsalva (TM) composite valve-conduit graft using cardiac magnetic resonance imaging and computational modelling technology
T2  - Journal of Cardiothoracic Surgery
UR  - http://dx.doi.org/10.1186/s13019-014-0193-6
UR  - http://hdl.handle.net/10044/1/26027
VL  - 9
ER  -

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