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Journal articleNyilas RD, Ng SML, Leung J, et al., 2005,
Towards a new geometric approach to assess the risk of rupture of abdominal aortic aneurysms using patient specific modelling
, Proceedings of the 2005 Summer Bioengineering Conference, Vol: 2005, Pages: 1246-1247- Cite
- Citations: 9
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Journal articleBorghi A, Wood NB, Mohiaddin RH, et al., 2005,
Computational modeling of fluid dynamics and stress pattern in thoracic aortic aneurysms
, Proceedings of the 2005 Summer Bioengineering Conference, Vol: 2005, Pages: 355-356- Cite
- Citations: 1
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Conference paperRicard F, Brechtelsbauer C, Xu XY, et al., 2005,
Monitoring of multiphase pharmaceutical processes using electrical resistance tomography
, 7th World Congress of Chemical Engineering, Publisher: ELSEVIER, Pages: 794-805, ISSN: 0263-8762- Author Web Link
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- Citations: 58
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Journal articleGlor FP, Ariff B, Hughes AD, et al., 2005,
Operator dependence of 3-D ultrasound-based computational fluid dynamics for the carotid bifurcation
, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 24, Pages: 451-456, ISSN: 0278-0062- Author Web Link
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- Citations: 21
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Conference paperRicard F, Brechtelsbauer C, Xu Y, et al., 2005,
Development of an electrical resistance tomography reactor for pharmaceutical processes
, 3rd World Congress in Process Tomography, Publisher: WILEY, Pages: 11-18, ISSN: 0008-4034- Author Web Link
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- Citations: 12
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Book chapterAugst AD, Ariff B, Barratt DC, et al., 2005,
Application of ultrasound-based computational fluid dynamics to modeling blood flow in the carotid bifurcation
, Medical Imaging Systems Technology: Volume 5: Methods in Cardiovascular and Brain Systems, Pages: 109-156Atherosclerotic plaque formation has been linked to haemodynamic risk factors, such as low and oscillating wall shear stresses (WSS). Experimental and numerical methods have been developed to investigate the mechanisms involved. Computational fluid dynamics (CFD) methods have the advantages of low cost and easily manageable numerical results. In order to obtain physiologically realistic results, CFD can be linked with medical imaging methods, which allow the extraction of in vivo vascular geometry and flow data to be used as input for haemodynamic simulations. Most of the image-based CFD approaches have been based on MRI, which has the disadvantages of relatively high cost and limited availability. Hence, a novel technique based on 3D ultrasound was developed with the advantages of low cost, fast acquisition and high spatial resolution. A methodology was developed to extract geometric information from the ultrasound images, reconstruct the surfaces and generate computational grids for flow simulations of the human carotid artery bifurcation. Additionally, a scheme was devised to utilize Doppler flow information for CFD boundary conditions. Accuracy and reproducibility of the combined imaging and modeling approach were evaluated in vitro and in vivo and the developed protocol was applied to normal subjects. The main conclusion of this work is the feasibility of 3D and Doppler ultrasound based CFD simulations for clinical applications. However, there are several limitations when applying this methodology in carotid bifurcations, i.e. the location of the carotid bulb relative to the jaw bone, which obscures the ultrasound path when the bifurcation is high in the neck. Future work should focus on minimizing the limitations and improve automation and reliability of image processing and reconstruction.
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Journal articleLee KW, Wood NB, Xu XY, 2004,
Ultrasound image-based computer model of a common carotid artery with a plaque
, MEDICAL ENGINEERING & PHYSICS, Vol: 26, Pages: 823-840, ISSN: 1350-4533- Author Web Link
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- Citations: 29
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Journal articleGlor FP, Ariff B, Hughes AD, et al., 2004,
Image-based carotid flow reconstruction: a comparison between MRI and ultrasound
, PHYSIOLOGICAL MEASUREMENT, Vol: 25, Pages: 1495-1509, ISSN: 0967-3334- Author Web Link
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- Citations: 48
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Journal articleGlor FP, Ariff B, Hughes AD, et al., 2004,
Influence of head position on carotid hemodynamics in young adults
, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 287, Pages: H1670-H1681, ISSN: 0363-6135- Author Web Link
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- Citations: 24
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Conference paperAugst A, Ariff B, Barratt D, et al., 2004,
Blood pressure not shear stress is related to intima-media thickness (IMT) over the entire carotid bifurcation
, 9th Annual Meeting of the European Council for Cardiovascular Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 566-566, ISSN: 0194-911X -
Conference paperHughes A, Ariff B, Stanton A, et al., 2004,
Differential efects of antihypertensive drugs on vascular structure
, 14th European Meeting on Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S201-S201, ISSN: 0263-6352 -
Journal articleMarshall I, Zhao SZ, Papathanasopoulou P, et al., 2004,
MRI and CFD studies of pulsatile flow in healthy and stenosed carotid bifurcation models
, JOURNAL OF BIOMECHANICS, Vol: 37, Pages: 679-687, ISSN: 0021-9290- Author Web Link
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- Citations: 169
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Conference paperAriff B, Zambanini A, Sarita V, et al., 2004,
Hemodynamic determinants of carotid artery structure in essential hypertension
, 19th Annual Scientific Meeting of the American-Society-of-Hypertension, Publisher: ELSEVIER SCIENCE INC, Pages: 131A-132A, ISSN: 0895-7061 -
Journal articleLeung J, Wright A, Cheshire N, et al., 2004,
Flow patterns and wall shear stresses in patient-specific models of the abdominal aortic aneurysm.
, Stud Health Technol Inform, Vol: 103, Pages: 235-242, ISSN: 0926-9630Abdominal Aortic Aneurysms (AAAs) are a major cause of death in Western societies. However, the factors responsible for the growth and ultimate rupture of AAA are not fully understood. Using computation fluid dynamics combined with CT images, the flow patterns and wall shear stress (WSS) in the AAA of a patient were studied. AAA geometry was obtained from images acquired during a routine CT scan, and a realistic abdominal aortic flow waveform was used as an upstream boundary condition. The computational results showed the presence of multiple flow recirculation zones and overall low WSS in the bulge of the aneurysm. This may provide some insight into the growth of thrombus in AAA.
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Journal articleGlor FP, Ariff B, Hughes AD, et al., 2004,
The integration of medical imaging and computational fluid dynamics for measuring wall shear stress in carotid arteries
, PROCEEDINGS OF THE 26TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, Vol: 26, Pages: 1415-1418, ISSN: 1094-687X- Author Web Link
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- Citations: 2
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Conference paperWood NB, Xu XY, 2004,
Turbulence in stenoses: Survey and early numerical results
, 4th International Conference on Fluid Mechanics, Publisher: TSINGHUA UNIVERSITY PRESS, Pages: 641-644- Author Web Link
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- Citations: 1
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Conference paperCheong PL, Bourne M, Griffith TM, et al., 2004,
Comparison of in vivo MRI measurements with numerical predictions
, Calgary, 2nd IASTED international conference on biomedical engineering, Innsburck, Austria, 16 - 18 February 2004, Publisher: Acta Press, Pages: 78-82 -
Conference paperMerrifield R, Long Q, Xu X, et al., 2004,
Combined CFD/MRI Analysis of Left Ventricular Flow
, MIAR 2003, Pages: 229-236 -
Journal articleGlor FP, Ariff B, Crowe LA, et al., 2003,
Carotid geometry reconstruction: a comparison between MRI and ultrasound
, MEDICAL PHYSICS, Vol: 30, Pages: 3251-3261, ISSN: 0094-2405- Author Web Link
- Cite
- Citations: 24
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Journal articleLong Q, Merrifield R, Yang GZ, et al., 2003,
The influence of inflow boundary conditions on intra left ventricle flow predictions
, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 125, Pages: 922-927, ISSN: 0148-0731- Author Web Link
- Cite
- Citations: 46
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