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• Conference paper
  Foin N, Torii R, Mortier P, De Beule M, Xu Y, Davies J, Di Mario Cet al., 2012,

  OPTIMISATION OF RESULTS IN BIFURCATION STENTING: INSIGHTS FROM BENCH MODELS, COMPUTATIONAL SIMULATIONS AND 3D OCT

  , 61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: E87-E87, ISSN: 0735-1097
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• Conference paper
  Prapa S, Mccarthy KP, Kilner PJ, Xu XY, Johnson MR, Ho SY, Gatzoulis MAet al., 2012,

  Biomechanical perspectives of thoracic aortic aneurysm formation in patients with a bicuspid aortic valve: an integrated analysis

  , 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S86-S86, ISSN: 0008-6363
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• Journal article
  Ma CYJ, Panoskaltsis N, Kumar R, Xu XY, Mantalaris Aet al., 2012,

  Simulation of <i>ex vivo</i> bone marrow culture: Application to chronic myeloid leukaemia growth model

  , BIOCHEMICAL ENGINEERING JOURNAL, Vol: 61, Pages: 66-77, ISSN: 1369-703X
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  • Citations: 9
• Journal article
  Liu D, Wood NB, Witt N, Hughes AD, Thom SA, Xu XYet al., 2012,

  Assessment of Energy Requirement for the Retinal Arterial Network in Normal and Hypertensive Subjects

  , JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 134, ISSN: 0148-0731
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  • Citations: 4
• Journal article
  Foin N, Toni R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY, Krams R, Di Mario Cet al., 2012,

  Kissing Balloon or Sequential Dilation of the Side Branch and Main Vessel for Provisional Stenting of Bifurcations Lessons From Micro-Computed Tomography and Computational Simulations

  , JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 5, Pages: 47-56, ISSN: 1936-8798
  • Author Web Link
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  • Citations: 88
• Journal article
  Wang Y, Pierce I, Gatehouse P, Wood N, Firmin D, Xu XYet al., 2012,

  Analysis of flow and wall shear stress in the peroneal veins under external compression based on real-time MR images

  , MEDICAL ENGINEERING & PHYSICS, Vol: 34, Pages: 17-27, ISSN: 1350-4533
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  • Citations: 12
• Conference paper
  Liu C, Krishnan J, Xu X-Y, 2012,

  An investigation of effects of drugs on solid tunmours within a systems-based mathematical modelling framework

  , Innovative simulation methods in healthcare
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• Journal article
  Tan FPP, Xu XY, Torii R, Wood NB, Delahunty N, Mullen M, Moat N, Mohiaddin Ret al., 2012,

  Comparison of Aortic Flow Patterns Before and After Transcatheter Aortic Valve Implantation

  , Cardiovascular Engineering and Technology, Vol: 3, Pages: 123-135

  Abstract—Little is known of the likely changes in blood flowvelocity profiles and aortic wall shear stress (WSS) followingtranscatheter aortic valve implantation (TAVI). The objectiveof this study was to investigate the effects of TAVI onflow patterns in the thoracic aorta by using cardiovascularmagnetic resonance imaging (CMR) and computational fluiddynamics (CFD). An elderly patient with aortic stenosis wasexamined using MRI pre- and post-TAVI, and CFDsimulations were carried out incorporating MRI-derivedpatient-specific anatomy and upstream flow conditions. Pre-TAVI velocity profiles demonstrated the highly disturbedturbulent flow and jet impacting the wall of the arch owing tothe partial opening of the stenosed aortic valve, with likelypathological effects. In the Post-TAVI aorta, velocity profileswere similar to those of healthy aortas with spatially moreuniform WSS and lower turbulence levels, demonstrating thefavourable effects of the TAVI procedure in restoring normalaortic flow. This study has shown both the effectiveness ofTAVI on an individual patient and the advantage of thecombined CMR and CFD method for a comprehensivepatient-specific assessment of pre- and post-TAVI aortic flowpatterns and WSS over CMR alone.

  • Abstract
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• Journal article
  Pierce IT, Gatehouse PD, Kalodiki E, Lattimer C, Geroulakos G, Xu XY, Firmin DNet al., 2012,

  Magnetic resonance venous velocity mapping during intermittent pneumatic compression of the calf and foot

  , Phlebology, Vol: 27, Pages: 352-359
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• Journal article
  Zhang X, Luckham PF, Hughes AD, Thom S, Xu XYet al., 2011,

  Development of lysolipid-based thermosensitive liposomes for delivery of high molecular weight proteins

  , INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 421, Pages: 291-292, ISSN: 0378-5173
  • Author Web Link
  • Open Access Link
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  • Citations: 13
• Journal article
  Liu C, Krishnan J, Xu XY, 2011,

  A systems-based mathematical modelling framework for investigating the effect of drugs on solid tumours

  , THEORETICAL BIOLOGY AND MEDICAL MODELLING, Vol: 8
  • Author Web Link
  • Open Access Link
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  • Citations: 10
• Journal article
  Su J, Gu Z, Xu XY, 2011,

  Discrete element simulation of particle flow in arbitrarily complex geometries

  , CHEMICAL ENGINEERING SCIENCE, Vol: 66, Pages: 6069-6088, ISSN: 0009-2509
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  • Citations: 58
• Conference paper
  Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Davies JE, Xu XY, Krams R, Di Mario Cet al., 2011,

  Sequential Side Branch and Main Vessel Dilatation instead of Kissing Balloon after Provisional Bifurcation Stenting: Lessons from Micro-CT and Computational Simulations

  , 23rd Annual Transcatheter Cardiovascular Therapeutics (TCT) Symposium, Publisher: ELSEVIER SCIENCE INC, Pages: B82-B82, ISSN: 0735-1097
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• Journal article
  Pierce IT, Gatehouse PD, Xu XY, Firmin DNet al., 2011,

  MR Phase-Contrast Velocity Mapping Methods for Measuring Venous Blood Velocity in the Deep Veins of the Calf

  , JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 34, Pages: 634-644, ISSN: 1053-1807
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  • Citations: 8
• Journal article
  Liu C, Krishnan J, Stebbing J, Xu XYet al., 2011,

  Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors

  , PHARMACOGENOMICS, Vol: 12, Pages: 1337-1348, ISSN: 1462-2416
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  • Citations: 12
• Journal article
  Tan FPP, Wood NB, Tabor G, Xu XYet al., 2011,

  Comparison of LES of Steady Transitional Flow in an Idealized Stenosed Axisymmetric Artery Model With a RANS Transitional Model

  , JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 133, ISSN: 0148-0731
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  • Citations: 35
• Conference paper
  Malkawi AH, Hinchliffe RJ, Xu XY, Pirianov G, Tornsey E, Loftus IM, Cockerill G, Thompson MMet al., 2011,

  Lamin A/C over- expression at regions exposed to high wall stress; A novel, mechano-sensitive pathway in abdominal aortic aneurysm (AAA) pathogenesis

  , Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 35-36, ISSN: 0007-1323
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• Journal article
  Starmans-Kool MJ, Stanton AV, Xu YY, Thom SAM, Parker KH, Hughes ADet al., 2011,

  High dietary salt intake increases carotid blood pressure and wave reflection in normotensive healthy young men

  , JOURNAL OF APPLIED PHYSIOLOGY, Vol: 110, Pages: 468-471, ISSN: 8750-7587
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  • Citations: 25
• Journal article
  Ariff BB, Glor FP, Crowe L, Xu XY, Vennart W, Firmin DN, Thom SM, Hughes ADet al., 2010,

  Carotid Artery Hemodynamics: Observing Patient-specific Changes with Amlodipine and Lisinopril by Using MR Imaging Computation Fluid Dynamics

  , RADIOLOGY, Vol: 257, Pages: 662-669, ISSN: 0033-8419
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  • Citations: 2
• Conference paper
  Malkawi AH, Hinchliffe RJ, Xu XY, Pirianov G, Torsney E, Loftus IM, Cockerill GW, Thompson MMet al., 2010,

  Lamin A/C Overexpression at Regions Exposed to High Wall Stress: A Novel, Mechanosensitive Pathway in Abdominal Aortic Aneurysm (AAA) Pathogenesis

  , Scientific Sessions on Arteriosclerosis, Thrombosis and Vascular Biology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E233-E233, ISSN: 1079-5642
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