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@inproceedings{Koutsos:2016:10.1109/ISCAS.2016.7527236,
author = {Koutsos, A and Kalofonou, M and Sohbati, M and Toumazou, C},
doi = {10.1109/ISCAS.2016.7527236},
pages = {325--328},
publisher = {IEEE},
title = {Epigenetic-IC: A fully integrated sensing platform for epigenetic reaction monitoring},
url = {http://dx.doi.org/10.1109/ISCAS.2016.7527236},
year = {2016}
}

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TY  - CPAPER
AB  - This paper presents a pH-based System-on-Chip DNA methylation quantification platform for real time monitoring of DNA methylation ratio in target genes. The architecture forms a novel autonomous system, capable of providing diagnostic information on the progression of a disease, notably cancer. The system is equipped with drift and trapped charge compensation schemes based on differential measurements and an auto-calibration algorithm. The simulated system in 0.35μm CMOS technology achieves a power consumption of 0.997mW, with a DNA methylation ratio output sensitivity of 0.1%. The ISFET-based detection platform occupies a total of 901um2 and allows the calculation of DNA methylation ratio in pH-monitored DNA methylation based reactions.
AU  - Koutsos,A
AU  - Kalofonou,M
AU  - Sohbati,M
AU  - Toumazou,C
DO  - 10.1109/ISCAS.2016.7527236
EP  - 328
PB  - IEEE
PY  - 2016///
SN  - 2379-447X
SP  - 325
TI  - Epigenetic-IC: A fully integrated sensing platform for epigenetic reaction monitoring
UR  - http://dx.doi.org/10.1109/ISCAS.2016.7527236
UR  - http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=11&SID=C6MQWHF6Hot727MmQai&page=1&doc=4
ER  -

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