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@inproceedings{Kalofonou:2014:10.1109/ISCAS.2014.6865514,
author = {Kalofonou, M and Toumazou, C},
doi = {10.1109/ISCAS.2014.6865514},
pages = {1832--1835},
publisher = {IEEE},
title = {An ISFET based analogue ratiometric method for DNA methylation detection},
url = {http://dx.doi.org/10.1109/ISCAS.2014.6865514},
year = {2014}
}

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TY  - CPAPER
AB  - This paper presents the concept of a ratiometric approach for DNA methylation detection using the “Methylation Cell” for the indication of epigenetic abnormalities related to cancer. The “Methylation Cell” allows real-time detection of pH signals resulting from DNA based reactions using ISFET sensors, performing continuous computation of the ratio of DNA methylation, giving a discrete output signal when DNA methylation exceeds a certain predefined percentage. Fabricated in a typical 0.35μm CMOS process, it uses current-mode translinear circuits to perform computation in low power. Experimental results are presented, demonstrating its capabilities through an integration in a Lab-on-Chip (LoC) set-up using a microfluidic assembly.
AU  - Kalofonou,M
AU  - Toumazou,C
DO  - 10.1109/ISCAS.2014.6865514
EP  - 1835
PB  - IEEE
PY  - 2014///
SN  - 0271-4302
SP  - 1832
TI  - An ISFET based analogue ratiometric method for DNA methylation detection
UR  - http://dx.doi.org/10.1109/ISCAS.2014.6865514
UR  - http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=21&SID=C6MQWHF6Hot727MmQai&page=2&doc=12
ER  -

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