Citation

BibTex format

@article{Georgiou:2007:10.1109/TBCAS.2007.893178,
author = {Georgiou, P and Toumazou, C},
doi = {10.1109/TBCAS.2007.893178},
journal = {IEEE Transactions on Biomedical Circuits and Systems},
pages = {39--49},
title = {A Silicon Pancreatic Beta Cell for Diabetes},
url = {http://dx.doi.org/10.1109/TBCAS.2007.893178},
volume = {1},
year = {2007}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The paper will consider how silicon devices such as ion-sensitive field effect transistors can be used to model metabolic functions in biology. In a first example, a biologically inspired silicon beta cell is presented to serve as the main building block of an artificial pancreas. This is to be used for real-time glucose sensing and insulin release for diabetics. This system presents the first silicon implementation of a metabolic cell capable of exhibiting variable bursting behavior upon glucose stimulation. Based on the Hodgkin and Huxley formalism, this approach achieves dynamics similar to that of biological beta cells by using devices biased in the subthreshold regime. In addition to mimicking the physiological behavior of the beta cell, the circuit achieves good power efficiency, measured to be 4.5 uW
AU - Georgiou,P
AU - Toumazou,C
DO - 10.1109/TBCAS.2007.893178
EP - 49
PY - 2007///
SP - 39
TI - A Silicon Pancreatic Beta Cell for Diabetes
T2 - IEEE Transactions on Biomedical Circuits and Systems
UR - http://dx.doi.org/10.1109/TBCAS.2007.893178
VL - 1
ER -

Contact us

Centre for Bio-Inspired Technology
Imperial College London
Bessemer Building
South Kensington
SW7 2AZ, UK

Tel: +44 (0)207 594 0701
Fax: +44 (0)207 594 0704

E-mail: bioinspired@imperial.ac.uk