Theme 3: Endothelial Resilience
From pathophysiology to a translational treatment target in CVD
Endothelial resilience refers to the remarkable ability of endothelial cells, which line the interior surface of blood vessels, to maintain functionality and adapt to various physiological challenges and stressors. These resilient cells play a pivotal role in regulating vascular tone, permeability, and inflammatory responses, thereby influencing overall cardiovascular health. Through intricate mechanisms endothelial cells exhibit resilience against factors such as oxidative stress, inflammation, and other noxious influences that harm the cardiovascular system. Our theme will aim to explore restoring as well as enhancing endothelial resilience, which is increasingly recognised as a key therapeutic target in preventing and managing cardiovascular diseases. Our work underscores the importance of maintaining endothelial health as a vital part of maintaining overall cardiovascular homeostasis and longevity.
Theme leads
Anna Randi
Anna Randi
Translational
Ramzi Khamis
Ramzi Khamis
Clinical
Co-applicants
Christopher Rhodes
Christopher Rhodes
Costanza Emanueli
Costanza Emanueli
Declan O’Regan
Declan O’Regan
Ed Tate
Ed Tate
Jesus Gil
Jesus Gil
Julia Gorelik
Julia Gorelik
Manuel Mayr
Manuel Mayr
Michela Noseda
Michela Noseda
Key investigators
Alastair Webb
Alastair Webb
Asha Patel
Asha Patel
Beata Wojciak-Stothard
Beata Wojciak-Stothard
Cesare Terracciano
Cesare Terracciano
Graeme Birdsey
Graeme Birdsey
Jane Mitchell
Jane Mitchell
Joseph Boyle
Joseph Boyle
Koralia Paschalaki
Koralia Paschalaki
Prashant Srivastava
Prashant Srivastava
General enquiries
BHF Centre of Research Excellence
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London W12 0NN
BHF Centre Manager
Mrs Jaya Rajamanie
j.rajamanie@imperial.ac.uk
+44 (0)20 7594 8062
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