Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated New and Views.

See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.

The mechanism of resistance to favipiravir in influenza. PNAS (2018).
Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

Citation

BibTex format

@article{Lipsitch:2016:10.7554/eLife.18491,
author = {Lipsitch, M and Barclay, W and Raman, R and Russell, CJ and Belser, JA and Cobey, S and Kasson, PM and Lloyd-Smith, JO and Maurer-Stroh, S and Riley, S and Beauchemin, CAA and Bedford, T and Friedrich, TC and Handel, A and Herfst, S and Murcia, PR and Roche, B and Wilke, CO and Russell, CA},
doi = {10.7554/eLife.18491},
journal = {eLife},
title = {Viral factors in influenza pandemic risk assessment},
url = {http://dx.doi.org/10.7554/eLife.18491},
volume = {5},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk.
AU  - Lipsitch,M
AU  - Barclay,W
AU  - Raman,R
AU  - Russell,CJ
AU  - Belser,JA
AU  - Cobey,S
AU  - Kasson,PM
AU  - Lloyd-Smith,JO
AU  - Maurer-Stroh,S
AU  - Riley,S
AU  - Beauchemin,CAA
AU  - Bedford,T
AU  - Friedrich,TC
AU  - Handel,A
AU  - Herfst,S
AU  - Murcia,PR
AU  - Roche,B
AU  - Wilke,CO
AU  - Russell,CA
DO  - 10.7554/eLife.18491
PY  - 2016///
SN  - 2050-084X
TI  - Viral factors in influenza pandemic risk assessment
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.18491
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391276700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/44932
VL  - 5
ER  -
Download

Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk