Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated New and Views.

See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.

The mechanism of resistance to favipiravir in influenza. PNAS (2018).
Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

Citation

BibTex format

@article{Riley:2021:10.1126/science.abf0874,
author = {Riley, S and Ainslie, KEC and Eales, O and Walters, CE and Wang, H and Atchison, C and Fronterre, C and Diggle, PJ and Ashby, D and Donnelly, CA and Cooke, G and Barclay, W and Ward, H and Darzi, A and Elliott, P},
doi = {10.1126/science.abf0874},
journal = {Science},
pages = {990--995},
title = {Resurgence of SARS-CoV-2: detection by community viral surveillance},
url = {http://dx.doi.org/10.1126/science.abf0874},
volume = {372},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Surveillance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has mainly relied on case reporting, which is biased by health service performance, test availability, and test-seeking behaviors. We report a community-wide national representative surveillance program in England based on self-administered swab results from ~594,000 individuals tested for SARS-CoV-2, regardless of symptoms, between May and the beginning of September 2020. The epidemic declined between May and July 2020 but then increased gradually from mid-August, accelerating into early September 2020 at the start of the second wave. When compared with cases detected through routine surveillance, we report here a longer period of decline and a younger age distribution. Representative community sampling for SARS-CoV-2 can substantially improve situational awareness and feed into the public health response even at low prevalence.
AU  - Riley,S
AU  - Ainslie,KEC
AU  - Eales,O
AU  - Walters,CE
AU  - Wang,H
AU  - Atchison,C
AU  - Fronterre,C
AU  - Diggle,PJ
AU  - Ashby,D
AU  - Donnelly,CA
AU  - Cooke,G
AU  - Barclay,W
AU  - Ward,H
AU  - Darzi,A
AU  - Elliott,P
DO  - 10.1126/science.abf0874
EP  - 995
PY  - 2021///
SN  - 0036-8075
SP  - 990
TI  - Resurgence of SARS-CoV-2: detection by community viral surveillance
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abf0874
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33893241
UR  - http://hdl.handle.net/10044/1/89736
VL  - 372
ER  -
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Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk