Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated New and Views.

See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.

The mechanism of resistance to favipiravir in influenza. PNAS (2018).
Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

Citation

BibTex format

@article{Scott:2020:10.1371/journal.ppat.1008716,
author = {Scott, C and Kankanala, J and Foster, TL and Goldhill, DH and Bao, P and Simmons, K and Pingen, M and Bentham, M and Atkins, E and Loundras, E and Eldertield, R and Claridge, JK and Thompson, J and Stilwell, PR and Tathineni, R and McKimmie, CS and Targett-Adams, P and Schnell, JR and Cook, GP and Evans, S and Barclay, WS and Foster, R and Griffin, S},
doi = {10.1371/journal.ppat.1008716},
journal = {PLOS PATHOGENS},
title = {Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza},
url = {http://dx.doi.org/10.1371/journal.ppat.1008716},
volume = {16},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Scott,C
AU  - Kankanala,J
AU  - Foster,TL
AU  - Goldhill,DH
AU  - Bao,P
AU  - Simmons,K
AU  - Pingen,M
AU  - Bentham,M
AU  - Atkins,E
AU  - Loundras,E
AU  - Eldertield,R
AU  - Claridge,JK
AU  - Thompson,J
AU  - Stilwell,PR
AU  - Tathineni,R
AU  - McKimmie,CS
AU  - Targett-Adams,P
AU  - Schnell,JR
AU  - Cook,GP
AU  - Evans,S
AU  - Barclay,WS
AU  - Foster,R
AU  - Griffin,S
DO  - 10.1371/journal.ppat.1008716
PY  - 2020///
SN  - 1553-7366
TI  - Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza
T2  - PLOS PATHOGENS
UR  - http://dx.doi.org/10.1371/journal.ppat.1008716
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000562656600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL  - 16
ER  -
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Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk