Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated New and Views.

See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.

The mechanism of resistance to favipiravir in influenza. PNAS (2018).
Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

Citation

BibTex format

@article{Dunning:2019:10.1038/s41590-019-0328-y,
author = {Dunning, J and Blankley, S and Hoang, LT and Cox, M and Graham, CM and James, PL and Bloom, CI and Chaussabel, D and Banchereau, J and Brett, SJ and MOSAIC, Investigators and Moffatt, MF and O'Garra, A and Openshaw, PJM},
doi = {10.1038/s41590-019-0328-y},
journal = {Nature Immunology},
pages = {373--373},
title = {Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.},
url = {http://dx.doi.org/10.1038/s41590-019-0328-y},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article.
AU  - Dunning,J
AU  - Blankley,S
AU  - Hoang,LT
AU  - Cox,M
AU  - Graham,CM
AU  - James,PL
AU  - Bloom,CI
AU  - Chaussabel,D
AU  - Banchereau,J
AU  - Brett,SJ
AU  - MOSAIC,Investigators
AU  - Moffatt,MF
AU  - O'Garra,A
AU  - Openshaw,PJM
DO  - 10.1038/s41590-019-0328-y
EP  - 373
PY  - 2019///
SN  - 1529-2908
SP  - 373
TI  - Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.
T2  - Nature Immunology
UR  - http://dx.doi.org/10.1038/s41590-019-0328-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30728492
UR  - http://hdl.handle.net/10044/1/67593
VL  - 20
ER  -
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Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk