BibTex format
@article{Reddy:2016:10.1089/dia.2015.0413,
author = {Reddy, M and Pesl, P and Xenou, M and Toumazou, C and Johnston, D and Georgiou, P and Herrero, P and Oliver, N},
doi = {10.1089/dia.2015.0413},
journal = {Diabetes Technol Ther},
pages = {487--493},
title = {Clinical Safety and Feasibility of the Advanced Bolus Calculator for Type 1 Diabetes Based on Case-Based Reasoning: A 6-Week Nonrandomized Single-Arm Pilot Study.},
url = {http://dx.doi.org/10.1089/dia.2015.0413},
volume = {18},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: The Advanced Bolus Calculator for Diabetes (ABC4D) is an insulin bolus dose decision support system based on case-based reasoning (CBR). The system is implemented in a smartphone application to provide personalized and adaptive insulin bolus advice for people with type 1 diabetes. We aimed to assess proof of concept, safety, and feasibility of ABC4D in a free-living environment over 6 weeks. METHODS: Prospective nonrandomized single-arm pilot study. Participants used the ABC4D smartphone application for 6 weeks in their home environment, attending the clinical research facility weekly for data upload, revision, and adaptation of the CBR case base. The primary outcome was postprandial hypoglycemia. RESULTS: Ten adults with type 1 diabetes, on multiple daily injections of insulin, mean (standard deviation) age 47 (17), diabetes duration 25 (16), and HbA1c 68 (16) mmol/mol (8.4 (1.5) %) participated. A total of 182 and 150 meals, in week 1 and week 6, respectively, were included in the analysis of postprandial outcomes. The median (interquartile range) number of postprandial hypoglycemia episodes within 6-h after the meal was 4.5 (2.0-8.2) in week 1 versus 2.0 (0.5-6.5) in week 6 (P = 0.1). No episodes of severe hypoglycemia occurred during the study. CONCLUSION: The ABC4D is safe for use as a decision support tool for insulin bolus dosing in self-management of type 1 diabetes. A trend suggesting a reduction in postprandial hypoglycemia was observed in the final week compared with week 1.
AU - Reddy,M
AU - Pesl,P
AU - Xenou,M
AU - Toumazou,C
AU - Johnston,D
AU - Georgiou,P
AU - Herrero,P
AU - Oliver,N
DO - 10.1089/dia.2015.0413
EP - 493
PY - 2016///
SP - 487
TI - Clinical Safety and Feasibility of the Advanced Bolus Calculator for Type 1 Diabetes Based on Case-Based Reasoning: A 6-Week Nonrandomized Single-Arm Pilot Study.
T2 - Diabetes Technol Ther
UR - http://dx.doi.org/10.1089/dia.2015.0413
UR - https://www.ncbi.nlm.nih.gov/pubmed/27196358
UR - http://hdl.handle.net/10044/1/39151
VL - 18
ER -