Alumni

Joined The Lab: 2001
Alumni
 Details
  Dr. Robin Kumar

Research Topic/Area: Oxygen Transport Simulation in the Human Bone Marrow
  Dr. Fabio Sidoli

Research Topic/Area: Systematic Development of a Coupled Population-Balance
Single-Cell Model for Mammalian Cell Cultures
  Dr. Wu Mon-Han

Research Topic/Area: The Effect of Osmotic Pressure on GS-NS0 Antibody Production Cell Line
 
Summary of the table's contents
Dr. Ir. Eirini Velliou

Nationality: Greek
E-mail:  e.velliou@imperial.ac.uk
Office Tel: +44 (0)20 75941224
Supervisors: Prof. Sakis Mantalaris and Prof. Stratos Pistikopoulos

Research Interest:

  • Stem cell scaffold bioprocessing.
  • Leukemic bioreactor cultivation.
  • Stem and leukemic environmental stress responses.
  • Leukemia.
  • Mathematical modeling of stem and leukemic cell bioprocessing.


Biography

Educational background
DateRole
 January 2008-December 2011 Katholieke Universiteit Leuven, Faculty of Engineering, Department of Chemical Engineering, Chemical and Biochemical Process Technology and Control Laboratory: PhD candidate.

PhD dissertation Title: Microbial inactivation in a liquid and a viscoelastic model system-Predictive modelling of heat adaptation phenomena after exposure to chaperones, metabolites and acids (ISBN 978-94-6018-467-3).
 September 2001–June 2006 National Technical University of Athens, School of Chemical Engineering.

MSc Chemical Engineering

Master Thesis: (September 2005-June 2006) Laboratory of Food Chemistry and Technology, Division IV, School of Chemical engineering, Thesis title: Kinetic study and validation of new enzymatic, photochemical and physicochemical Time Temperature Integrators (TTI) for the Chill Chain Management of foods.
 1999-2001  High school degree from Greek apolyterion: 19,5/20 (first)
 
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Work experiences
DateRole
 2012-present

Post-doctoral Research Engineer at the Centre of Process Systems Engineering (CPSE), Department of Chemical Engineering, Faculty of Engineering, Imperial College London (Scientific Project-MOBILE)

Research Area: Stem and Leukemic Cell Bioengineering:

-Three dimensional stem cell culture systems.
-Leukaemic bone marrow biomimicry.
-Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism.
-Autophagy.
-In vitro chemotherapy.
-Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems.
 2012 Post-doctoral Research Engineer at the Bioengineering group (GEBI) of the Earth and Life Institute (ELI), Univerité Catholique de Louvain, Louvain-la-Neuve, Belgium.

Research area: (Micro-) Algal Biotechnology.

-Overall Research Objective: Detection, quantification and further optimisation of the production of valuable metabolic products (such as lipids, carotenoids etc) from green microalgae in liquid state and after immobilization, at micro-scale (high throughput technical platforms) and pilot scale (photobioreactors).
 2008-2011 Research Engineer in the Chemical and Biochemical Process Technology and Control Laboratory, Department of Chemical Engineering, Faculty of Engineering, Katholieke Universiteit Leuven, Belgium.

Research area: Predictive Microbiology.

-Overall Project Objective: The experimental study and further mathematical modeling of the microbial heat resistance, as a result of exposure to acids, (extra)cellular metabolites, molecular chaperones and immobilization (in a solid model system).
 2006-2007 Research Engineer in the Laboratory of Food Chemistry and Technology of the School of Chemical Engineering, National Technical University of Athens, Greece.

Participation in European and National research projects in the field of Bioprocess and Food Engineering:

Research area: Bioprocess and Food Engineering:

-Experimental design and mathematical modeling of Time Temperature integrators (TTI) for the chill chain management as well as for control of thermal industrial processes.
-Study and validation of microbial and enzymatic inactivation kinetics with High Hydrostatic Pressure technology.
-Nanoemulsion design for (Food) Nanotechnological Applications.
-food traceability.
 2005 ALUMINUM DE GRECE, Division of electrolysis, Department of aluminum production Viotia, Greece

-Study, Validation and mathematical modeling of the functional parameters of an electrolytic pool.
 
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Research Title

Research in the field of Stem and Leukemic Cell Bioprocessing and Optimization:

  • Stem cell scaffold bioprocessing.
  • Leukemic bioreactor cultivation.
  • Stem and leukemic environmental stress responses.
  • Leukemia.
  • Mathematical modeling of stem and leukemic cell bioprocessing.

Selected Publications

Articles in International Journals

  • Noriega, E., Velliou E.,  Van Derlinden, E., Mertens, L., Van Impe, J. (2014) Role of growth morphology in the formulation of NaCl-based selective media for injury detection of Escherichia coli, SalmonellaTyphimurium and Listeria innocua. (submitted).
  • Velliou, E., Li, J., Bochenek, M., Jeffryes, C., Agathos, S.N. (2014) Growth evolution of Botryococcus braunii as influenced by light intensity, nitrogen availability and shear stress (submitted).
  • Li, J., Stamato, M., Velliou, E., Jeffryes C., Agathos, S.N. (2014) Design, characterization and cultivation of microalgae in an airlift flat panel photobioreactor (su bmitted).
  • Velliou, E., Noriega, E., Van Derlinden, E., Mertens, L., Geeraerd, A., Devlieghere, F., Van Impe, J. (2013). The effect of colony formation on the heat inactivation dynamics of  Escherichia coli K12  and Salmon ella Typhimurium. Food Research International, 54(2), 1746-1752.
  • Noriega, E., Velliou E., Van Derlinden, E., Mertens, L., Van Impe, J. (2013) Effect of immobilization on the heat-induced sublethal injury of Escherichia coli, Salmonella Typhimuri um and Listeria innocua. Food Microbiology, 36(2), 355-364.
  • Velliou, E., Van Derlinden, E., Cappuyns, A., Geeraerd, A., Devlieghere, F., Van Impe, J. (2012). Heat inactivation of Escherichia coli MG1655: Effect of microbial metabolites and acids in spent medium. Journal of Thermal Biology 37(1), 72-78.
  • Velliou, E., Van Derlinden, E., Cappuyns, A.,Goossens, J., Geeraerd, A., Devlieghere, F., Van Impe, J. (2011). Heat adaptation of Escherichia coli MG1655: effect of acid and glucose. Procedia Food Science,  1, 987-993.
  • Velliou, E., Van Derlinden, E., Cappuyns, A., Aerts, D., Nikolaidou, E., Geeraerd, A., Devlieghere, F., Van Impe, J. (2011). Quantification of the influence of Trimethylamine-N-Oxide (TMAO) on the heat resistance of Escherichia coli K12 at lethal temperatures. Letters in Applied Microbiology, 52(2), 116-122.
  • Tsironi, T., Stamatiou, A., Giannoglou, M., Velliou, E., Taoukis, P. (2011). Predictive modelling and selection of Time Temperature Integrators for monitoring the shelf life of modified atmosphere packed gilthead seabream fillets. LWT - Food Science and Technology, 44(4), 1156-1163.
  • Velliou, E., Van Derlinden, E., Cappuyns, A., Nikolaidou, A., Geeraerd, A., Devlieghere, F., Van Impe, J. (2011). Towards the quantification of the effect of acid treatment on the heat tolerance of Escherichia coli K12 at lethal temperatures. Food Microbiology , 28, 702-711.
  • Tsironi, T., Gogou, E., Velliou, E., Taoukis, P. (2008). Application and Validation of the TTI based chill chain management system SMAS (Safety Monitoring and Assurance System) on shelf life optimization of vacuum packed chilled tuna. International Journal of Food Microbiology, 128(1), 108-115.

Selected Conferences

  • E. Velliou,  M. Fuentes Gari, R. Misener, E. Pefani, M. Rende,  N. Panoskaltsis, A. Mantalaris, E.N. Pistikopoulos (2014) A framework for the design, modelling and optimisation of biomedical systems, Proceeding of the 8thInternational Conference on Foundations on Computer Aided Process Design-FOCAPD, Washington, USA, July 13-17, 2014 Invited Paper
  • E. Velliou, S. Brito Dos Santos, M. Fuentes Gari, R. Misener  N. Panoskaltsis, E. N. Pistikopoulos, A. Mantalaris (2014) Evolution of an AML model system under oxidative & starvation stress: A comparison between two and three dimensional cultures. TERMIS-EU Meeting 2014 (Tissue Engineering and Regenerative Medicine) Annual Meeting, Genova, Italy, June 10-13, 2014 (submitted).
  • M. Fuentes Gari, R. Misener , D. Garzia-Munzer, E. Velliou, N. Panoskaltsis, E. N. Pistikopoulos, A. Mantalaris (2014) Development and experimental validation of cyclin-based population balance model  of the cell cycle in leukaemia cell lines (Tissue Engineering and Regenerative Medicine) Annual Meeting, Genova, Italy, June 10-13, 2014 (submitted).
  • R. Misener, M. Allenby, M, Fuentes Gari, M. Rende, E. Velliou, N. Panoskaltsis, E. N. Pistikopoulos, A. Mantalaris (2014) Optimisation under uncertainty for a bioreactor that produces red blood cells  (Tissue Engineering and Regenerative Medicine) Annual Meeting, Genova, Italy, June 10-13, 2014 (submitted).
  • M. Fuentes, E. Velliou, R. Misener, N. Panoskaltsis, A. Mantalaris, E.N. Pistikopoulos (2014). Towards the design of optimal personalised treatments for Acute Myeloid Leukemia (AML), Advanced Process Modelling Forum (APM) 2014, London, UK, April 2-3, 2014.
  • R. Misener, J., Chin, M. Lai, M. Fuentes Gari, Rende, M., E. Velliou, N. Panoskaltsis, A. Mantalaris, E.N. Pistikopoulos (2014) Robust Superstructure Optimisation of a Bioreactor that Produces Red Blood Cells, European Symposium on Computer Aided Process Engineering (ESCAPE 24), Budapest, Hungary, June 15-18, 2014 (accepted).
  • E. Velliou, M. Fuentes Gari, S. Brito Dos Santos, R. Misener  N. Panoskaltsis, A. Mantalaris, E. N. Pistikopoulos (2013) The effect of oxygen and glucose stress on the evolution of a leukaemia model system in an in vitro bone marrow mimicry. 13th AIChE (American Institute of Chemical Engineers) Annual Meeting, San Francisco, California, USA, November 3-8, 2013.
  • M. Fuentes Gari, E. Velliou, R. Misener, S. Brito Dos Santos, N. Panoskaltsis, A. Mantalaris, E. N. Pistikopoulos (2013) Towards personalised treatment of Acute Myeloid leukaemia: The impact of considering the cell cycle. 13th AIChE Annual Meeting, San Francisco, California, USA, November 3-8, 2013.
  • E. Pefani, N. Panoskaltsis, E. Velliou, M. Fuentes Gari, A. Mantalaris, M.C. Georgiadis, E.N. Pistikopoulos (2013) An automated system for the design of optimal personalized chemotherapy protocols for the treatment of leukaemia. 13th AIChE Annual Meeting, San Francisco, California, USA, November 3-8, 2013.
  • R. Misener, J., Chin, M. Lai, M. Fuentes Gari, Rende, M., E. Velliou, N. Panoskaltsis, E.N. Pistikopoulos, A. Mantalaris, (2013) Optimising a bioreactor that produces red blood cells under uncertainty, 2nd Belgian Symposium on Tissue Engineering, Leuven, Belgium, October 24-25, 2013. Winner: Best Poster Award
  • Noriega, E., Velliou, E., Van Derlinden, E., Mertens, L., Van Impe, J. (2013) Role of food structure on the heat-induced sublethal injury of Escherichia coli, Salmonella Typhimurium and Listeria innocua. 5th Congress of European Microbiologists, FEMS2013, Leipzig, Germany, July 21-25, 2013.
  • Velliou, E., E. Pefani, M. Fuentes, N. Panoskaltsis, A. Mantalaris, M. Georgiadis, E..N. Pistikopoulos (2013). A platform for the design of optimal personalised treatment of Acute Myeloid Leukaemia (AML), Advanced Process Modelling Forum (APM) 2013, London, UK, April 17-18, 2013.
  • Noriega, E., Velliou, E., Van Derlinden, E., Van Impe, J. (2012) Role of food structure on the heat-induced sublethal injury of Escherichia coli, Salmonella Typhimurium and Listeria innocua. FoodMicro2012, Istanbul, Turkey, September 3-7, 2012.
  • Li, J., Jeffryes, C., Stamato, M., Velliou, E., Demarche, P., Nair, R., Bouhaija, E., Junghanns, C., Agathos, S.N. (2012) Design, characterization and cultivation of microalgae in an airlift flat panel photobioreactor. APCAB 2012-Algae for the Future (8th Asia-Pacific Con f erence on Algal Biotechnology and 1st International Conference on Coastal Biotechnology), Adelaide, Australia, July 9-12, 2012.
  • Van Derlinden, E., Mertens, L., Velliou, E., Noriega, E., Van Impe, J. (2012) Effect of immobilization on the inactivation dynamics of food pathogens. Abstract book of the 6th International Symposium on Food Rheology and Structure, (Eds): P. Fischer, E.J. Windhab. 6th International Symposium on Food Rheology and Structure, Zürich, Switzerland, April 10-13, 2012.
  • Velliou, E., Van Derlinden, E., Mertens, L.,Cappuyns, A., Geeraerd, A., Devlieghere, F., Van Impe, J. (2011). Effect of a gelified matrix on the heat inactivation of E. coli and Salmonella Typhimurium. 7th International Conference on Predictive Modeling in Foods. Dublin, Ireland, September 12-15, 2011.
  • Velliou, E., Van Derlinden, E., Cappuyns, A., Goossens, J., Geeraerd, A., Devlieghere, F., Van Impe, J. (2011). Heat adaptation of Escherichia coli K12: effect of acid shock and glucose. 11th International Conference on Engineering and Food. Athens, Greece, 22-26 May 2011.
  • Velliou, E., E. Van Derlinden, A.M. Cappuyns, A.H. Geeraerd, F. Devlieghere, J. F. Van Impe (2010). The effect of structured environment on the inactivation of E. coli K12 at lethal temperatures. 22nd Symposium of the International Committee on Food Microbiology and Hygiene (ICFMH) FoodMicro2010, Copenhagen, Denmark, August 30 - September 3 2010.
  • P. Busschaert, E. Velliou, E. Van Derlinden, M. Uyttendaele, A.H. Geeraerd and J.F. Van Impe (2010). Estimation of inactivation model parameters using a Bayesian approach
  • 22nd Symposium of the International Committee on Food Microbiology and Hygiene (ICFMH) FoodMicro2010, Copenhagen, Denmark, August 30 - September 3 2010.
  • E. Velliou, E. Van Derlinden, A. M. Cappuyns, A. Vermeulen, E. Nikolaidou, A.H. Geeraerd, F. Devlieghere, J. F. Van Impe (2009). Quantifying the effect of (in)organic acids on the thermal inactivation of Escherichia coli. BioMicroWorld 2009: III International Conference on Environmental, Industial and Applied Microbiology, Lisbon, Portugal, 2-4 December 2009.
  • E. Velliou, E. Van Derlinden, A. Cappuyns, E. Nikolaidou, A.H. Geeraerd, F. Devlieghere, J.F. Van Impe (2009). The effect of pre-acid shock, on the heat resistance of Escherichia coli K12 at lethal temperatures. 6th International Conference on Predictive Microbiology in Foods, Washington D.C. USA, 8-12 September 2009.
  • E. Velliou, P.J. D'Huys, E. Van Derlinden, A.H. Geeraerd, J.F.Van Impe (2009). Adaptation of Escherichia coli K12 at lethal temperatures: consequences of heat   pre-treatment of the medium and acidic pre-history. First International Conference on MICROBIAL STRESS from molecules to systems, Semmering, Austria 7-10 May 2009.
  • E. Velliou, E. Van Derlinden, D. Aerts, E. Nikolaidou, A.H. Geeraerd, F. Devlieghere, J.F. Van Impe (2009). The influence of Trimethylamine-N-Oxide (TMAO) on the  heat resistance of Escherichia coli K12 at lethal temperatures. First International Conference on MICROBIAL STRESS from molecules to systems, Semmering, Austria 7-10 May 2009.
  • Tsironi T., Tsevdou M., Velliou E., Taoukis P. (2008). Implementation and application of mathematical models for choosing the ideal map-package of fish fillets (Sparus aurata). 1st Pan-Hellenic Conference of Packaging for Foods and Beverages 2008 March 2008, Athens, Greece.
  • Gogou E., Velliou E., Kriekouki A., Taoukis P. (2007). Xylanase Based Inetgrators for Evaluating  Thermal and High Hydrostatic Pressure Processes. EFFoST/EHEDG Conference 2007, November 2007, Lisbon, Portugal.
  • Velliou E., Taoukis P., Gogou E. (2007). Study and validation of state of the  art Time Temperature Integrators for monitoring shelf life of food products in the chill chain Institute of  Food Technologists 2007 Αnnual Meeting, July-August 2007, Chicago, Illinois, USA.
  • Velliou E., Gogou E., Katapodis P., Giannakourou M., Christakopoulos P., Taoukis P. (2007). Study and Validation of Food Thermal Processing with the use of Time Temperature Integrators (ΤΤΙ)  Pythagoras Conference for the Scientific Research in the NTUA, July 2007 Plomari, Mitilini, Greece.
  • Velliou E., Gogou E., Taoukis P. (2007). Kinetic Study of New Time Temperature Indicators (TTI) for the Chill Chain Management of food. 6th National Scientific Conference of Chemical Engineering, May-June 2007, Athens, Greece.

 
Chapter in book

  • Velliou, E., Juneja, V., Van Impe, J., Van Derlinden, E. Modelling the induced thermotolerance due to heat, acid shock and rising temperatures, In:  J. F. Van Impe and V. P. Valdramidis, (eds.) Modelling of Industrial Food Thermal Processes, Nova Science Publishers Inc., Hauppauge, New York, USA (ISBN: 978-1-62100-842-2).

 
Teaching

Lectures

Member of the teaching team of Advanced Bioprocess Engineering, taught in: MSc in Advanced Chemical Engineering, Department of Chemical Engineering, Faculty of Engineering, Imperial College London:

  • Cellular Metabolism
  • Biostatistics (Design of Experiments (DoE), Anova)
  • Bioreactors

Master thesis supervision-daily guidance

  • Master Thesis of Susana Britos Dos Santos, academic year 2012-2013: The effect of glucose and oxygen stress on the in vitro cultivation of AML and CLL cell lines in a three dimensional bone marrow mimicry system, Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Faculty of Engineering, Imperial College London.
  • Master Thesis of Jef Goossens, academic year 2010-2011: Het effect van glucose en azijnzuur op de groei en inactivatie van Escherichia coli K12 (The effect of glucose and acids on the growth and inactivation kinetics of Escherichia coli K12), Chemical and Biochemical Process Technology and Control Laboratory, Department of Chemical Engineering, Faculty of Engineering, Katholieke Universiteit Leuven.
  • Master Thesis of Dieter Aerts, academic year 2008-2009: Invloed van temperatuur op micro-organismen onder constante en dynamische condities (Influence of temperature on micro-organisms under static and dynamic conditions) Chemical and Biochemical Process Technology and Control Laboratory, Department of Chemical Engineering, Faculty of Engineering, Katholieke Universiteit Leuven.
  • Master Thesis of Efstathia Nikolaidou (Erasmus student from NTUA, Greece), academic year 2009-2010: The case of heat stress adaptation, Chemical and Biochemical Process Technology and Control Laboratory, Department of Chemical Engineering, Faculty of Engineering, Katholieke Universiteit Leuven, in collaboration with the Laboratory of Food Chemistry and Technology, School of Chemical Engineering, National Technical University of Athens.
  • Master Thesis of < span style="text-decoration: underline;">Christina Katsiki (NTUA, Greece), academic year 2008-2009: Nanotechnological applications in food systems, Laboratory of Food Chemistry and Technology, School of Chemical Engineering, National Technical Un iversity of Athens.

 
Supervision, teaching and guidance of bachelor students, Faculty of Engineering, Katholieke Universiteit Leuven

  • Academic years 2009-2010 and 2010-2011: ‘Bioindicator: a dynamic durability date’, (experimental design and validation of a microbiological and a enzymatic Time Temperature Indicatior),Chemical and Biochemical Process Technology and Control Laboratory, Department of Chemical Engineering, Faculty of Engineering, Katholieke Universiteit Leuven.
  • Academic year 2008-2009: ‘Production of glycerol from glucose via cultivation of Zaccharomyces Cerevisiae’, Chemical and Biochemical Process Technology and Control Laboratory, Depa rtment of Chemical Engineerin g, Faculty of Engineering, Katholieke Universiteit Leuven.


Awards/Funding

  • 2014: ERC-Bio-blood
  • 2012-2013: ERC- MOBILE
  • 2012: FOTOBIOMAT
  • 2008-2011: Research Council Katholieke Universiteit Leuven, OPTEC-Optimization in Engineering, SCORES4CHEM-Belgian Industrial Research Fund, Belgian Program on Interuniversity Poles of Attraction.
  • 2006-2007: Freshlabel, Pythagoras, PABET2003, MoniQA.
Dr. Maria Rende

Nationality: Italian
E-mail: m.rende@imperial.ac.uk
Office: ACEX Room 1M5, BSEL, Chemical Engineering Dept., South Kensington Campus.
Office Tel: +44 (0)20 75941225
Supervisors: Prof. A. Mantalaris

Research Interests:
Scaffolds and bioreactors for tissue regeneration, cell bioprocessing, cell therapy and drug screening.

Biography:

Academic background
DateRole
 2013-present  Senior Research Associate, BSEL, Imperial College London, UK.
 2008-2013  Research Associate, BSEL, Imperial College London, UK.
 2005-2008  PhD in Chemical Engineering and Materials, Università degli Studi della Calabria, Italy.
 2002  Degree in Biology, Unversità degli Studi della Calabria, Italy.
 
Summary of the table's contents

Research Title
Development of a Bio-Inspired Blood Factory for Personalised Healthcare-BioBlood

Publications

Articles in International Journals

  • M. Rende, H. Macedo, T. Mortera-Blanco, A. Livingston, K. Li, N. Panoskaltsis and A. Mantalaris. Perfused three-dimensional hollow fibre bioreactor: novel bio-inspired platform for long-term culture of human hematopoietic cells. (Submitted Artif.Organs)
  • R. Misener, M. Fuentes Garí, M. Rende, Velliou E., N. Panoskaltsis, S. Pistikopoulos, A. Mantalaris. Global Superstructure Optimisation of Red Blood Cell Production in a Parallelised Hollow Fibre Bioreactor. Computers & Chem. Eng 2014
  • T. Mortera-Blanco, M. Rende, H. Macedo, S. Farah, A. Bismarck, A. Mantalaris, N. Panoskaltsis. Ex vivo mimicry of normal and abnormal human hematopoiesis. Journal of Visualized Experiments (JoVE) 2012; 62. DOI: 10.3791/3654
  • S. Morelli, A. Piscioneri, S. Salerno, M. Rende, C. Campana, F. Tasselli, A. De Vito, G. Giusi, M. Canonaco, Enrico Drioli and L. De Bartolo. Flat and tubular system for the reconstruction of hippocampal neuronal network. J Tissue Eng Regen Med  2012; 6(4):299-313
  • G. Giusi, R. M. Facciolo, M. Rende, R. Alo, A. Di Vito, S. Salerno, S. Morelli, L. De Bartolo, E. Drioli, M. Canonaco. Distinct α subunits of the GABAA receptor are responsible for early hippocampal silent neuron-related activities. Hippocampus 2009; 19(11):1103-1114
  • L. De Bartolo, S. Salerno, E. Curcio, A. Piscioneri, M. Rende, S. Morelli, F. Tasselli, A. Bader, E. Drioli. Human hepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials 2009; 30(13):2531-2543
  • L. De Bartolo, M. Rende S. Morelli, G. Giusi, S. Salerno, A. Piscioneri, A. Gordano, A. Di Vito, M. Canonaco, E. Drioli. Influence of membrane surface properties on the growth of neuronal cells isolated from hippocampus. J Membrane S  2008; 325(1): 139-149
  • L . De Bartolo, A. Piscioneri, G. Cotroneo, S. Salerno, F. Tasselli, C. Campana, S. Morelli, M. Rende, MC Caroleo, M. Bossio, E. Drioli. Human lymphocyte PEEK-WC hollow fiber membrane bioreactor. J Biotechnol 2007; 132: 65-75
  • S. Morelli, S. Salerno, M. Rende, L.C. Lopez, P. Favia, A. Procino, B. Memoli, V.E. Andreucci, R. dAgostino, E. Drioli and L. De Bartolo. Human hepatocyte functions in galactosylated membrane bioreactor.  J Membrane S 2007. 3029(1-2):27-35.
  • L. De Bartolo, S. Morelli, M. Rende, C. Campana, S. Salerno, N. Quintiero, E. Drioli. Human hepatocyte morphology and functions in a multibore fiber bioreactor. Macromol Bioscience 2007; 7(5):671-680
  • L. De Bartolo, S. Morelli, M. Rende, S. Salerno, L. Giorno, LC Lopez, P. Favia, R. d’Agostino, E. Drioli. Galactose derivative immobilized glow discharge processed polyethersulfone membranes maintain the liver cell metabolic activity. J Nanosci and Nanotechnol 2006; 6(8): 2344–2353
  • L. De Bartolo, S. Morelli, L. Giorno, C. Campana, M. Rende, S. Salerno, S. Maida, E. Drioli. Polyethersulfone membrane bio hybrid system using pig hepatocytes: Effect of diclofenac on cell biotransformation and synthetic functions. J Membrane S 2006; 278(1-2):133-143.
  • L. De Bartolo, S. Salerno, L. Giorno, S. Morelli, G. Barbieri, E. Curcio, M. Rende, E. Drioli. Membrane bioreactor using pig hepatocyte for in vitro evaluation of anti-inflammatory drugs. Catal today 2006; 118(1-2):172-180.
  • L. De Bartolo, S. Salerno, S. Morelli, L. Giorno, M. Rende, B. Memoli, A. Procino, V.E. Andreucci, A. Bader, E. Drioli. Long-term maintenance of human hepatocytes in oxygen permeable membrane bioreactor. Biomaterials 2006; 27(27): 4794-4803
  • E. Curcio, L. De Bartolo, G. Barbieri, M. Rende, L. Giorno, S. Morelli, E. Drioli. Diffusive and convective transport through hollow fibre membranes for liver cell culture. J Biotechnol 2005; 117(3):309-321
  • L. De Bartolo, S. Morelli, M.C. Gallo, C. Campana, G. Statti, M. Rende, S. Salerno, E. Drioli. Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC-polyuretane membranes. Biomaterials 2005; 26(33):6625-6634
  • L. De Bartolo, S. Morelli, L.C. Lopez, L. Giorno, C. Campana, S. Salerno, M. Rende, P. Favia, L. Detomaso, R. Gristina, R. d’Agostino, E. Drioli. Biotransformation and liver-specific functions of human hepatocytes in culture on RGD-immobilized plasma-processed membranes. Biomaterials 2005; 26(21):4432-4441
  • L. De Bartolo, S. Morelli, M. Rende, A. Gordano and E. Drioli. New Modified Polyetherketone Membrane for Liver Cell Culture in Biohybrid System: Adhesion and Specific functions of Isolated Hepatocytes. Biomaterials 2004; 25(17):3621-3629

 Book Chapters

  • T. Mortera, M. Rende, N. Panoskaltsis and A. Mantalaris. 5.26-Tissue Engineering of Normal and Abnormal Bone Marrow.  In M. Caplan Ed: The Reference Module in Biomedical Science. Elsevier (2014-in publication)
  • S. Morelli, S. Salerno, A. Piscioneri, M. Rende, C. Campana, L. De Bartolo. Membrane approaches for liver and neuronal tissue engineering. In: E. Drioli (Eds.) Comprehensive Membrane Science and Engineering. Volume 3, pp. 229–252 Oxford: Academic Press.Elsevier 2010, pp.229-252.
  • S. Morelli, S. Salerno, A. Piscioneri, M. Rende, C. Campana, L. De Bartolo, E. Drioli. Membrane bioreactors for regenerative medicine: an example of the bioartificial liver. Asia-Pacific Journal of Chemical Engineering 2009.
  • S. Morelli, S. Salerno, A. Piscioneri, M. Rende, C. Campana, E. Drioli, L. De Bartolo. Membranes in regener a tive medicine and tissue engineering. In: Membrane Operations: Innovative Separations and Transformations; Wiley VCH, E. Drioli, L. Giorno (eds.), 1st Ed. – April 2009; ISBN-10: 3-527-32038-5 pp.433-44 6
  • L. De Bartolo, M. Rende, G. Giusi, S. Morelli, A. Piscioneri, M. Canonaco, E. Drioli. “Membrane bio-hybrid systems: a valuable tool for the study of neuronal activities”. In: M. Canonaco and R.M. Facciolo (Eds.) Evolutionary Molecular Strategies and Plasticity 2007; Research Signpost, pp.379-396.

International Proceedings

  • M. Rende, N. Panoskaltsis, R. Morilla, A. Mantalaris. Novel Successful Cytokine-free Culture of Acute Leukemic Cells in a Perfused Hollow-Fiber Bioreactor. Tissue Engineering and Regenerative Medicine 2014. 8:48-48 TERMIS-EU, Genoa, IT, 10-14 July 2014. Peer-reviewed and Published
  • E. Velliou, M. Fuentes-Garí, R. Misener, E. Pefani, M. Rende, N. Panoskaltsis, A. Mantalaris, E. N Pistikopoulos. A framework for design, modeling and optimization of biomedical systems In: 8th International Conference on Foundations of Computer-Aided Process Design edited by: Mario Eden, John D. Siirola and Gavin P. Towler.  FOCAPD 2014. 34:225-236 Elsevier B.V.M. Peer-reviewed and Published
  • R. Misener, M. C. Allenby, M. Fuentes Garí, M. Rende, E. Velliou, N. Panoskaltsis, S. Pistikopoulos, A. Mantalaris. Optimisation Under Uncertainty for a Bioreactor that Produces Red Blood Cells. TERMIS-EU, Genoa, IT, 10-14 July 2014. Peer-reviewed
  • M. Rende, A. Mantalaris, R. Morilla, N. Aqel,  and N. Panoskaltsis. Biology Of Mixed Phenotype Acute Leukemia In Successful Long-Term Cytokine-Free Three-Dimensional (3D) Static and Perfused 3D Hollow-Fibre Bioreactor Culture. Blood 2013. 122(21):2603. ASH, American Society of Hematology, New Orleans, Louisiana, US, 7-10 Dec 2013. Peer-reviewed and published.
  • R. Misener, J. Chin, M. Lai, M. Fuentes Gari, M. Rende, E. Velliou, N. Panoskaltsis, E. N. Pistikopoulos, A. Mantalaris. Optimising a Bioreactor that Produces Red Blood Cells under Uncertainty. BSTE, 2nd Belgian Symposium on Tissue Engineering, Leuven, BE, 24-25 Dec 2013. Peer-reviewed.
  • M. . Rende, T. Mortera, N. Panoskaltsis and A. Mantalaris Bio-inspired Three-dimensional (3D) Platform For Ex vivo Study Of Normal And Abnormal Haematopoiesis. BSTE, 2nd Belgian Symposium of Tissue Engineering, Leuven, BE, 24-25 Oct 2013. Peer-reviewed
  • M. Rende, I. Fauzi, T. Mortera, J.M. da Costa Medeiros, A. Mantalaris, and Panoskaltis N., Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-Free In Vitro Human Bone Marrow Biomimicry. Blood 2012; 120(21):276. ASH, American Society of Hematology, Atlanta, US, 8-12 Dec 2012. Peer-reviewed and published.
  • M. Rende, T. Mortera, N. Aqel, S. Ryley, R. Morilla, Mantalaris A., and Panoskaltis N., Ex Vivo Three-Dimensional (3D) Functional biomimicry for the Long-Term Cytokine-Free Culture of Human Primary Acute Myeloid Leukemia (AML). Blood 2012; 120(21):48. ASH, American Society of Hematology. Peer-reviewed and online published.
  • M. Rende, T. Mortera Blanco, H. Macedo, A.G. Livingston, K. Li, N. Panoskaltsis, A. Mantalaris. Development of a perfused, three-dimensional (3D) human bone marrow mimicry that supports the long-term maintenance and expansion of human cord blood hematopoietic stem progenitor cells in the absence of exogenous cytokines. TERMIS, Tissue Engineering and Regenerative medicine, North America, Houston (TX), US, 11-14 Dec 2011. Peer-reviewed
  • M. Rende, H. Macedo, A. G. Livingston, L. Kang, N. Panoskaltis, and A. Mantalaris, Long-Term, Cyokine-Free Ex-vivo Expansion of Human Cord Blood Mononuclear Cells Using a Novel Closed-Loop  3D Dual Hollow fibre Pefused Bioreactor. Blood 2010; 116(21):828. ASH, American Society of Hematology, Orlando, US, 4-7 Dec 2010. Peer-reviewed and published
  • M. Rende, H. Macedo, T. Mortera Blanco, I. Baptista, A.G. Livingston, A. Mantalaris, N. Panoskaltsis, A novel 3D hollow fibre reactor for culture of human haematopoietic cells. J Hematol and Stem Cell Biol and Transplant 2009; 37(9):S101. ISEH, 38th International Society for Hematology and Stem Cells, Annual Scientific Meeting, Athens, Greece, 9-10 Sept 2009. Peer-reviewed and published
  • A. Di Vito, E. Avolio, G. Giusi, R. Alo, S. Morelli, M. Rende, L. De Bartolo, E. Drioli, M. Canonaco, Alpha2 GABAA receptor subunit plays a key role on hippocampal neuronal formations of hibernanting rodent. J Neurochem 2009; 110:84. European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Jul 11-14, 2009 Leipzig, Germany. Peer-reviewed and published
  • L. De Bartolo, S. Morelli, S. Salerno, A. Piscioneri, M. Rende, C. Campana, E. Drioli, Development of membrane biohybrid systems for liver and neuronal tissue engineering. Int J Art Organs 2009; 32(7):409. Peer-reviewed and published.
  • L. . De Bartolo, S. Salerno, E. Curcio, A. Piscioneri, M. Rende, F. Tasselli, A. Bader, E. Drioli. Crossed hollow fiber membrane bioreactor using human hepatocytes for in vitro study of drugs and metabolic diseases. Euromembrane, Montpellier France, 6-10 Sept 2009. Peer-reviewed
  • S. Salerno, A. Piscioneri, S. Morelli, M. Rende, C. Campana, A. Bader, E. Drioli L. De Bartolo. Membrane biohybrid systems for liver tissue engineering. Tissue Eng Part A 2008; 14(5):755. Termis, Porto, Jun 2008. Peer-reviewed and published
  • S. Salerno, A. Piscioneri, S. Morelli, S. Laera, M. Rende, P. Favia, E. Drioli, A. Bader, L. De Bartolo. Membrane biohybrid systems for liver tissue engineering. Int Journal of Art Organs 2008; 31(7):586-587. Peer-reviewed and published
  • M. Rende,  S. Morelli, G. Giusi, S. Salerno, A. Piscioneri, S. Giordano, M. Canonaco, E. Drioli, Effect of Membrane Surface on Hippocampal Neuronal Cell Differentiation. Tissue Eng Part A 2008; 14(5):254. Termis-EU Meeting, Porto, Portugal, 22-26 Jun 2008. Peer-reviewed
  • L. De Bartolo, S. Salerno, A. Piscioneri, M. Rende, C. Campana, E. Drioli Bioactive membranes for liver tissue engineering. ICOM, International Congress on Membranes and Membrane Processes, Honolulu, Hawaii Jul 2008. Peer-reviewed
  • L. De Bartolo, M. Rende, G. Giusi, S. Morelli, A. Piscioneri, F. Tasselli, S. Salerno, M. Canonaco, E. Drioli. Hollow fiber membranes for neuronal cell differentiation. 8th World Biomaterials Congress, Amsterdam, 28 May-1 Jun 2008. Peer-reviewed
  • A. Di Vito, G. Giusi, M. Rende, R. M. Facciolo, L. De Bartolo, E. Drioli, M. Canonaco. Neuronal elongation processes of hippocampal pyramidal cells depend on GABAA α5 subunit activities. 10th Int. Neuroscience Winter Conference, Solden - Austria, 5-10 Apr 2008
  • L. De Bartolo, M. Rende, G. Giusi, S. Morelli, A. Piscioneri, M. Canonaco and E. Drioli. Neuronal Membrane Bio-Hybrid System. 21th European Conference on Biomaterials, September 09-12 2007, Brighton, UK. Peer-reviewed
  • L. De Bartolo, S. Morelli, L.C. Lopez, L. Giorno, , G. Barbieri, S. Salerno, M. Rende, E. Curcio, A. Procino, P. Favia, B. Memoli, V.E. Andreucci, R. d’Agostino, E. Drioli. Human Galactosylated membrane bioreactor for long-term maintenance of liver specific functions. Desalination 2006; 1-3:147-149. Peer-reviewed and published
  • L. De Bartolo, S. Morelli, S. Salerno, C. Campana, A. Piscioneri, M. Rende, A. Bader, E. Drioli Modified polyetherketone-polyurethane membranes elicit human hepatocyte specific responses. Int J Artif Organs 2006;  29; (5):525. Peer-reviewed and published
  • L. De Bartolo, A. Piscioneri, S. Morelli, Rende M.,G. Cotroneo, F. Tasselli, M.C. Caroleo, E. Drioli. Human lymphocyte hollow fiber bioreactor. Desalination 2006; 199(1-3):141-143. Peer-reviewed and published
  • L. De Bartolo , S. Morelli, S., Salerno, S., Campana, C., Piscioneri, A., Rende M., Bader, A., Drioli, E. Novel bioactive polymeric membranes to elicit specific human hepatocyte responses. Desalination 2006; 199(1-3):261-262. Peer-reviewed and published
  • E Curcio, G. Barbieri, L . De Bartolo, M . Rende, S. Morelli, L. Giorno, E. Drioli. Diffusive and convective transport in HF membrane reactors for biomedical applications. Desalination 2006; 199(1-3):135-137. Peer-reviewed and published.
  • L. De Bartolo, S. Morelli, L.C. Lopez, L. Giorno, G. Barbieri, S. Salerno, M. Rende, E. Drioli. Human galactosylated membrane bioreactor for the long-term maintenance of liver specific functions. Desalination 2006; 199(1-3):147-149. Peer-reviewed and published.
  • L.&nbs p;De Bartolo, S. Salerno, S. Morelli, L. Giorno, M. Rende, B. Memoli, V.E. Andreucci, E. Drioli. Hepatocellular functions of human liver cells in oxygen-permeable membrane device. Desalination 2006; 200(1-3):488-490. Peer-reviewed and published.
  • L. De Bartolo, C. Campana, S. Salerno, S. Morelli, A. Piscioneri, M. Rende, A. Bader, E. Drioli. Specific functions and Diazepam biotransformation by human hepatocytes in a membrane bioreactor model. Cytotherapy 2006; 8(2):50. Peer-reviewed and published.
  • L. De Bartolo, S. Morelli, C. Campana, M.C. Caroleo, T. Siciliano, M. Rende, S. Salerno, E. Drioli. Effect of hypericum perforatum extract and interaction with diclofenac on hepatocytes cultured on polyethersulfone membranes. Int J Artif Organs 2005; 28(4):368. 2nd World Congress on Regenerative Medicine 2005. 18-20 May, G ermany . Peer-reviewed and published.
  • L. De Bartolo, S. Morelli, L.C. Lopez, M. Ren de, S. Salerno, A. Procino, P. Favia, B. Memoli, V.E. Andreucci, R. d’Agostino, E. Drioli. PES membranes modified by biomolecule immobilization for hepatocyte culture: effect of IL-6 on hepatocyte metabolism. 2nd World Congress on Regenerative Medicine, Int J Art Organs 2005; 28(4):292. Peer-reviewed and published.
  • L . De Bartolo, S. Morelli, M.C. Gallo, C. Campana, G. Statti, M. Rende, S. Salerno, E. Drioli. Long-term maintenance of human liver specific functions on PEEK-WC_PU membranes: effect of isoliquiritigenin on hepatocyte viability and functions. 2nd World Congress on Regenerative Medicine, Int J Art Organs  2005; 28(4):291. Peer-reviewed and published.
  • L. De Bartolo, S. Morelli, L.C. Lopez, L. Giorno, G. Barbieri, S. Salerno, M. Rende, E. Curcio, A. Procino, P. Favia, B. Memoli, V.E. Andreucci, R. d’Agostino and E. Drioli. Human Hepatocytes on Galactose- Immobilized Plasma Processed Membranes In A Bioreactor For The In Vitro Study Of IL-6 Effect. 19thEuropean Conference on Biomaterials 2005, Naples (Italy). Peer-reviewed.
  • L. De Bartolo, S. Morelli, L.C. Lopez, L. Giorno, G. Barbieri, S. Salerno, M. Rende, E. Curcio, A. Procino, P. Favia, B. Memoli, V.E. Andreucci, R. d’Agostino and E. Drioli. Human Hepatocytes on Galactose- Immobilized Plasma Processed Membranes In A Bioreactor For The In Vitro Study Of IL-6 Effect. 19thEuropean Conference on Biomaterials 2005, Naples (Italy). Peer-reviewed.

Awarded Presentations

2013

  • Invited speaker at the 2nd Belgian Symposium of Tissue Engineering (BSTE)

M. Rende, T. Mortera, N. Panoskaltsis and A. Mantalaris. Bio-Inspired Three-dimensional Platform for Ex vivo Study of Normal and Abnormal Haematopoiesis. BSTE, Leuven, 24-25 Oct

2013

Awarded Poster: 2nd Belgian Symposium of Tissue Engineering (BSTE)

R. Misener, J. Chin, Min Lai, M. Fuentes Gari, M. Rende, E. Velliou, N. Panoskaltsis and A. Mantalaris. Optimising a Bioreactor that Produces Red Blood Cells under Uncertainty. BSTE, Leuven, 24-25 Oct.

2011

Biotechnology Yes Competition, Business Plan for a Hypothetical Biotech Company. 6th-8th Oct, Yorkshire and Humben Weetwood Hall, Leeds; 13th Dec, Parc Plaza County Hall, London. My team was placed with Hema Stem Company in the Top Ten Business Plans in the UK.

2004

Awarded Poster: L. De Bartolo, S. Morelli, L. Giorno, C. Campana, M. Rende, G. Barbieri, E. Curcio, E. Drioli. Small-scale membrane bioreactor for in vitro drug metabolism studies of isolated hepatocytes. Euromembrane, Hamburg, 28 Sep-1Oct.


Teaching

2014

Co-supervising two PhDs, one RA and one Erasmus students in BSEL (Imperial College):

  • Development of a bio-inspired in silico-in vitro platform: towards personalised healthcare thorough optimisation of bone marrow mimicry bioreactor
  • Development of a three-dimensional bone marrow biomimicry
  • Effect of oxygen and glucose concentration on in vitro differentiation of umbilical blood mononuclear cells
  • Investigation of the movement of microparticles in 3D cell cultures for drug release

Helping with literature review, assisting with day-to-day supervision, offering experimental advice, and providing SOPs.

2013

Co-supervised two MSc projects in BSEL (Imperial College):

  • Functional bio-mimic platform for leukemic cell growth
  • Development of Porous 3D Polyurethane scaffolds as a Platform to Study in vitro Erythropoiesis

Formulated and designed MSc projects, helped the students with literature review, assisted them with day-to-day supervision, offered experimental advice, provided SOPs, assisted them with data analysis and interpretation, and marked their theses and dissertations.

2012

Co-supervised two BSc projects in BSEL (Imperial College)

Helped with literature review and assisted with day-to-day supervision, offered experimental advice.

2009-2013

Participated in UG lab-Bacterial fermentation (Imperial College)

Gave small group tutorials

Mentored pupils during their summer research placements. Duration: from 1 to 3 weeks.

2007-2010

Co-supervised three MSc projects in Department of Animal Physiology (University of Calabria):

  • Culture of hippocampal neurons in a hollow fibre membrane system
  • Biohybrid membrane system for the culture of neuronal cells isolated from hippocampus
  • Chitosan membrane for the culture of neuronal cells

2002

Taught in the Physiology course, Department of Biology (University of Calabria)

Was an internal examiner for fourth year Physiology.


Awards/Funding

I have actively been involved in the preparation of the following successful grant proposals submitted by my current supervisor, Prof. A. Mantalaris.

2014

Seventh Framework Programme: Development of a Bio-Inspired Blood Factory for Personalised Healthcare. Grant agreement number: 340719. £2.5 million. Duration 60 months.

2013

Travel grant to participate at the 2nd Belgian Symposium of Tissue Engineering (BSTE) £450.

2013

Contributor to the patent EP 2652119 A1 with 3% revenue share.

2009-2012

The Richard Thomas Leukaemia Found (RTLF): Study of leukaemia in 3D bioreactors. £ 120k. Duration 48 months.

2006

Member of the organizing committee board of Euromembrane 2006, September 24 - 28, Giardini Naxos, Taormina (Messina), IT.

 
Others

2010 Awarded Top Ten Business Plan in UK for a Hypot hetica l Biotech Co mp any in the Biotechnology Yes Competition.
2004 Awarded presentation: “Small-scale membrane bioreactor for in vitro drug metabolism studies of isolated hepatocytes” Euromembrane 2004, Hamburg, Germany.

Joined The Lab: 2002
Alumni
 Details
  Dr. Wesley Randle

Research Topic/Area: Tissue Engineering of Bone from Embryonic Stem Cells
  Dr. Ho Yingswan

Research Topic/Area: Elucidating the Effects of Varying Osmotic Pressure on the Antibody Production Process in GS-NS0 Cells
  Dr. Cleo Kontoravdi

Research Topic/Area: Towards the Optimization of the Production of Monoclonal Antibodies - Advanced Modelling, Experimental  Validation and Control Optimization Studies
  Dr. Laleh Safinia

Research Topic/Area: Preparation & Surface Characterization of Polymer Constructs for Tissue Engineering Applications
 
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Dr. Iliana Fauzi (Lia)

Nationality: Malaysian
E-mail: iliana.fauzi05@imperial.ac.ukDr. Lia Fauzi.
Office: ACEX Room 1M4, Chemical Engineering Dept., South.
Kensington Campus Imperial College London SW7 2AZ.
Office Tel:  +44 (0) 2075941224.
Supervisors: Prof. Athanasios Mantalaris & Dr. Nicki Panoskaltsis.

Research Interests:

  • Embryonic stem (ES) cells/ human ES cells (hESCs) & human induced pluripotent stem cells (hIPs).
  • Cord Blood stem cells.
  • Hematopoiesis, Erythropoiesis, Hemogenic-Endothelial cells differentiation.
  • 3 dimensional (3D) culture system i.e. Hydrogel Encapsulation.
  • Bioreactor.

Biography

Academic background
DateRole
 2014 Post doctoral Research Associate, Chemical Engineering Department, Imperial College London, UK - Bio-artificial Lung project (endothelial cells formation)
 2012-2013 Visiting Researcher (Post-doctoral Research Associate), Medicine and Chemical Engineering Department, Imperial College London, UK - Blood making project
 2006-2011 PhD in Stem Cells Bioprocessing, Chemical Engineering Department, Imperial College London, UK - Red blood cells production 
 2005-2011 Tutor at Faculty of Science and Engineering, Universiti Malaysia Terengganu (UMT), Malaysia
 2005 Research Assistant at Reconstructive Science Unit, School of Medical and Health, Universiti Sains Malaysia (USM), Malaysia
 2002-2005 BSc (Hons) in Biological Sciences, Universiti Malaysia Terengganu (UMT), Malaysia
 
Summary of the table's contents

Research Topic

Embryonic stem cells (ESCs) differentiation towards hematopoietic and erythroid lineage i.e. Red blood cells (RBCs) using HepG2 conditoned medium, alginate hydrogel encapsulation and rotating wall vessels bioreactor

 
Publications/Presentations

Journals

  • Placzek MR, Chung IM, Macedo HM, Ismail S, Blanco TM, Lim M, Cha JM, Fauzi I, Kang Y, Yeo DCL, Ma CYJ, Polak JM, Mantalaris A. Stem Cell Bioprocessing: Fundamentals and Principles. Journal of the Royal Society Interface 2009;6(32):209-32. http://rsif.royalsocietypublishing.org/content/6/32/209.long
  • Fauzi I, Panoskaltsis N, Mantalaris A. Enhanced hematopoietic differentiation towards erythrocytes from murine embryonic stem cells with HepG2-conditioned. Stem Cells Dev.  http://online.liebertpub.com/doi/abs/10.1089/scd.2012.0030
  • Fauzi I, Panoskaltsis N and Mantalaris A. Early Exposure of Murine Embryonic Stem Cells to Hematopoietic Cytokines Differentially Directs Definitive Erythropoiesis and Cardiomyogenesis in Alginate Hydrogel Three-Dimensional. Stem Cells Dev. 2014 Aug 5. [Epub ahead of print]  http://online.liebertpub.com/doi/pdf/10.1089/scd.2014.0105
  • Song K, Mantalaris A, Fauzi I, Macedo HM, Panoskaltsis N. Ex vivo expansion of human cord blood (CD 34+) cells encapsulated in cytokine containing hydrogels and a rotating wall vessel bioreactor (Submitted for Experimental Hematology Journal).
  • Cha JM*, Bariani C*, Chung IM, Ismail S, Fauzi I, Yeo DCL, Paopo I, Blanco TM, Rende M, Macedo HM, Tangviriyasirikul S, Mantalaris A. Bioprocessing applications to Embryonic Stem Cells: in vitro generation of bone, cartilage and heart cells  (Submitted).
  • Rende M, Fauzi I, Blanco TM, Da Costa Medeira JM, Mantalaris A, Panoskaltsis N. Physiologic erythropoiesis with enhanced globin switching and endogenous cytokine production in a long-term serum-free in vitro human bone marrow biomimicry (Manuscript in preparation for Blood Journal).
  • Fauzi I, Panoskaltsis N and Mantalaris A. Direct cardiomyogenesis from murine embryonic stem cells exposed to HepG2 CM and hematopoietic factors (Manuscript in preparation for Stem Cells Journal).

 
Abstracts

  • 54th Annual Scientific Meeting of American Society of Haematology (ASH), Atlanta, Georgia (December 8-11, 2012). Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-Free In Vitro Human Bone Marrow Biomimicry (Oral Presentation).
  • 52nd Annual Scientific Meeting of American Society of Haematology (ASH), Orlando, Florida (December 4th -7th 2010). A Novel, Three Dimensional (3D) Culture System for the Efficient, Single-Step Erythropoietic Differentiation of Mouse Embryonic Stem Cells (mESCs) (Poster presentation).
  • Stem Cells Networks lectures organised by Imperial College National Heart and Lung Institute (NHLI) (January 12th 2010).
  • 38th Annual Scientific Meeting of the International Society of Experimental Hematology (ISEH)-Society for Hematology and Stem cells, Athens, Greece (September 9th-12th, 2009). Single-step erythropoietic culture from mouse embryonic stem cells using hydrogels, HepG2-conditioned medium and a bioreactor (Poster presentation).
  • UMT-MSD Postgraduate Seminar, Leeds, UK (May 12th-13th, 2009). Production of hematopoietic cells from mouse embryonic stem cells using HepG2-conditioned medium (Proceedings).
  • Annual Conference and exposition of Tissue Engineering International and Regenerative Medicine Society (TERMIS), North America (NA), San Diego (December7th-10th, 2008). Production of hematopoietic cells from mouse embryonic stem cells using HepG2-conditioned medium (Poster presentation).
  • 8th Symposium of Applied Biology, Putrajaya, Malaysia (June 22nd-23rd, 2005). Cytotoxic effect of Acanthamoeba lysates on T-Lymphoblastic leukemic cell line (CEM-SS) (Proceedings).

 
Teaching

  • 2005 - 2006 : Tutor and Demonstrator for Biological Organism (II), Cell and Tissue Culture, and Animal Anatomy and Physiology for one semester in Dept. of Biological Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu (UMT), Malaysia.
  • 2004: Lab Demonstrator - Cell and tissue Culture in Dept. of Biological Sciences, Facul ty of Science and Technology, Universit i Malaysia Terengganu (UMT), Malaysia.

 
Awards/Funding

  • UK-ASEAN Knowledge Partnership Mobility Scheme (2012-2013).
  • Richard Thomas Leukaemia Fund (2009-2013).
  • Graduate Studies Abroad Program by Malaysian Academic Training Scheme, Scholarship awarded for PhD students from Ministry of Education Malaysia (2006-2010).
  • Scholarship awarded for Excellent Bachelor Degree students Scheme from Public Service Department of Malaysia (2002-2005).
  • Scholarship awarded for Excellent Matriculation College students from Public Service Department of Malaysia (2001-2002).

 
Others

International Membership in Societies:

  • Member of American Society of Hematology (ASH)
  • Member of Tissue Engineering and Regenerative Medicine Society (TERMIS)
  • Member of International Society of Experimental Hematology (ISEH)
  • Member of UK/Eire Malaysian Postgraduate Association -MPA
  • Member of Malaysian Postgraduates Council-London – MPGC
  • Member of Imperial College Alumni- Chemical Engineering PhD
Joined The Lab: 2003
Alumni
 Details
  Dr. Ines Baptista

Research Topic/Area: Microbial Dynamics in Biological Systems Degrading Halogenated Organic Compounds
  Dr. Sandeep A Chandarana

Research Topic/Area: Fluid Dynamics in Microgravity Bioreactors
   Dr. Hwang Yu-Shik

Research Topic/Area: Skeletal Tissue Engineering Using Embryonic Stem Cells
 
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Joined The Lab: 2004
Alumni
 Details
  Dr. Ismail Siti Norhayati

Research Topic/Area: Tissue Engineering of Pneumocytes: Production of Pneumocytes from Embryonic Stem Cells using Bioreactor
  Dr. Lam Ming-Chi (Carolyn)

Research Topic/Area: In Silico Dynamic Optimisation Studies for Batch/Fed-batch Mammalian Cell Suspension Cultures Producing Biopharmaceuticals
  Dr. Lim Mayasari

Research Topic/Area: Towards an Integrated Spatial, Temporal, On-line, Real-time Biosensing Platform for Stem Cell and Tissue Engineering Applications
  Dr. Ma Chi-Yip (Joan)

Research Topic/Area: Development and Modelling of a 3-D Perfused Bone Marrow Culture System
  Dr. Teresa Mortera Blanco

Research Topic/Area: Cord Blood expansion and Acute Myeloid Leukemia culture ex vivo.
 
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Joined The Lab: 2005
Alumni
 Details
  Dr. Kang Yunyi

Research Topic/Area: Characterisation of a Conditioned Media for Enhanced Mesoderm Differentiation
  Dr. Chung I-Ming

Research Topic/Area: Rational Design of Surface Through the Quantification of Adhesion: Controlling Cellular Behaviour for Tissue Engineering Applications
  Dr. Ye Hua (Cathy)

Research Topic/Area: Cord Blood Stem Cells Proliferation
  Dr. Mark Placzek

Research Topic/Area: Expansion of Embryonic Stem Cells in 3D Bioreactor Culture
  Dr. Cha Jae Min

Research Topic/Area: A Novel Design of 3D-Bioprocess for Embryonic Stem Cell Expansion and Differentiation: in vitro Skeletal Lineage Tissue Generation
 
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Joined The Lab: 2006
Alumni
 Details
  Dr. Hugo Macedo

Research Topic/Area: Towards the large-scale production of human red blood cells
 
Summary of the table's contents
Joined The Lab: 2007
Alumni
 Details
  Dr. Soh Boon Seng

Research Topic/Area: Optimization of Human Embryonic Stem Cells Culture and their Differentiation towards the Lung Lineage
  Dr. David Yeo

Research Topic/Area: 3-D Technologies for ESC bioprocessing and bioprocess design
  Dr. Idtisak Paopo (Ting)

Research Topic/Area: The Airlift Bioreactor for Lung Cell Production
  Dr. Supacharn Tangviriyasirikul (Oak)

Research Topic/Area: Development of a Perfused Bioreactor with Mechanical Stimulation for Bone or Cartilage Tissue Engineering
 
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Joined The Lab: 2008
Alumni
 Details
  Dr. Alexandros Kiparissides

Research Topic/Area: Development of a Combined Mathematical and Experimental Framework for the Control and Optimisation of Mammalian Cell Culture Systems
  Dr. Anne Delille (in a colloboaration with PaCE )

Research Topic/Area: Green Renewable Composite Materials and large scale
 
Summary of the table's contents
Joined The Lab: 2009
Alumni
 Details
  Dr. Saiful Zubairi

Research Topic/Area: Development of an Ex-vivo 3-D Model of Chronic Lymphocytic Leukemia (CLL)
 
Summary of the table's contents
Left the lab: 2015
Alumni
 Details
 
‌		  
 
Summary of the table's contents
                   
‌

Dr. Chonlatep Usaku


Research Topic/Area: Modelling of apoptosis for the control and optimisation of mammalian cell culture systems
                      
‌		 Dr. Anastasia Georgiou

Research Topic/Area: Mineralized Three-Dimensional Cellular Constructs from Embryonic Stem Cells for Bone Tissue Engineering
                      

Dr. Gizem Buldum

Research Topic/Area: Bacterial cellulose production                                                                                                                                   
                     
‌		 Dr. Argyro Tsipa

Research Topic/Area: Closing the loop, from in silico to in vivo; modelling and optimisation of bacterial cell culture systems
                      
‌		 Dr. Maria Fuentes-Gari

Research Topic/Area: Population balance model of the cell cycle in leukaemia for the optimization of chemotherapy treatments
                      
‌		 Dr. Xiaomei Lu

Research Topic/Area:  Endothelial cell differentiation from embryonic stem cells and adult stem cells.                                            
David Garcia Munzer

Nationality: Colombian / Spanish
Email: dgarciam@imperial.ac.uk
Office: Room C509, 5/F Roderic Hill Building, Chemical Engineering Dept., South Kensington Campus.
Supervisor(s):  Prof. A. Mantalaris and Prof. E. N. Pistikopoulos

Research Interests:
Mammalian cell cultures, modelling and optimization


Biography

Academic background
DateRole
 2010-2014  PhD in Chemical Engineering, Imperial College London, UK
 2007-2010  Scale-up and Optimization Engineer, Dow Chemical Company, EU
 2005-2007 MSc Biochemical Engineer, Delft University of Technology, The Netherlands

Master thesis: Design Molecules for Top-Tier Fuels
 2000-2005 Industrial Engineer,University of Los Andes, Colombia

Graduation Project: Application of Decision’s Models and Risk Evaluation on the Exploration, Drilling, and Petroleum Exploitation
 1999-2004 Chemical Enginee, University of Los Andes, Colombia

Graduation Project: Obtaining polyols from Palm Oil
 
Summary of the table's contents

Research title

Population balance modelling in cell culture systems

Publications/Presentations

  • Conference Paper: “A Cyclin Distributed Cell Cycle Model in GS-NS0”. Accepted for ESCAPE 24 – Budapest, Hungary (2014).
  • ESACT Proceedings 2013. “Dynamic Cyclin Profiling as a Tool to Segregate the Cell Cycle”. García Münzer D.G., Kostoglou M., Georgiadis M.C., Pistikopoulos E.N., Mantalaris A.
  • ESACT Proceedings 2013. “Cell Cycle and Apoptosis: A map for the GS-NS0 cell line at the genetic level and the link to environmental stresses”.  Usaku C., García Münzer D.G., Pistikopoulos E.N., Mantalaris A.
  • “Developing a Cyclin Blueprint as a Tool for Mapping the Cell Cycle in GS-NS0”. García Münzer D.G., Kostoglou M., Georgiadis M.C., Pistikopoulos E.N., Mantalaris A. 2013. Biochemical Engineering Journal, Volume 81, 15 December 2013, Pages 97-107.
  • Oral Presentation:  “Mapping the Cell Cycle in GS-NS0: Developing a cyclin blueprint as a tool for optimizing productivity”. AIChE Annual Meeting, 2012, Pittsburgh - USA.
  • “Biofiltration of Volatile Organic Compounds by a Fluidized Bed of Sawdust”. Delebarre A., Andres Y., Pellerano M., Pero P., García Münzer D.G.. International Journal of Chemical Reactor Engineering, Vol 5, 2007, ISSN 1542-6580, DOI: 10.2202/1542-6580.1402

 
Research Experience

Imperial College London (2010 – 2014)

Development of modelling and experimental approaches that facilitate the study of cell cultures as a sum of subpopulations with individual growth/metabolic and productivity characteristics.

The Dow Chemical Company (2007 – 2010)

Research Assignment Program (RAP)

  • 1st Assignment. Plastics Technical Service & Development
  • 2nd Assignment. Performance Fluids R&D
  • 3rd Assignment. Water Solutions – Reverse Osmosis
  • Scale-up & Optimization – PU Process R&D


MSc Biochemical Engineering. TUDelft - Shell Global Solutions (2007)
"Design Molecules for Top-Tier Fuels"

As part of a large program on "new fuel formulations" an explorative study on new molecules based on streams from Shell's chemicals plants. The focus of this thesis is the generation and evaluation of options for a first process design of the promising route to produce the desired molecule.

R&D Industrial Internship. DSM Anti-Infectives (2006)

Improvement and optimization of seed train cultivations.

Graduation Project. Industrial Engineering. University of Los Andes (2005)

“Application of Decision’s Models and Risk Evaluation on the Exploration, Drilling, and Petroleum Exploitation”

The subject is the investigation of the state of art of the decision analysis tools employed in the petroleum industry.

Graduation Project. Chemical Engineering. University of Los Andes (2005)

“Obtaining polyols from Palm Oil”

A process of exploration and optimization to obtain polyols from palm oil, emphasizing on epoxydation.

Research Internship. ECOLE DES MINES DE NANTES (2004)

A study was made in a fluidized bed bioreactor to decontaminate BTX in airflow.

Industrial Internship. REPSOL QUIMICA S.A. (2004)

Study of the control system performance to the industrial site in Tarragona. The project covers the handling of alarm data of each process plant, metric’s calculation, analysis and evaluation.
 

Awards/Funding

  • 2010: Multi-scale Computational Modeling of Chemical/Biochemical Systems, Marie Curie Actions

 
Others

Languages:
SPANISH: Native
ENGLISH: Fluent
FRENCH: Conversational
Grades Average:
8.29/10 (Cum Laude, Delft University of Technology)
4.23/5 (Faculty’s highest 10%, University of Los Andes)

Nihal Almuraikhi

Nationality: Saudi
E-mail: n.almuraikhi09@imperial.ac.uk
Office: Room c509, Roderic Hill building, Centre for Process Systems Engineering,Department of Chemical Engineering, Imperial College London, South Kensington Campus
Office Tel:  +44 (0) 2075941224
Supervisors:  Prof. Mantalaris and  Dr. Panoskaltsis

Research Interests:

  • Human Induced Pluripotent Stem Cells
  • Stem cell bioprocessing
  • Haematology
  • Erythropoiesis
  • Cell culture
  • Molecular Biology.

Biography

Academic background
DateRole
 2010-Present  PhD in Stem Cell Bioprocessing at Imperial College London, London, UK.
 2008-2009  MSc in Stem Cell Technology at the University of Nottingham, UK
 2002-2006 BSc degree in Applied Medical Sciences, Medical Laboratory Technology at King Faisal University, Saudi Arabia
 
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Teaching Assistant Activities

[2011- Present] a lecturer at the Stem Cell Unit, Medical School, King Saud University, Saudi Arabia

 [December 2009- August 2010] Saad Research and Development Center, Saudi Arabia

  • Writing and reviewing grants and research proposals for King Abdulaziz City for Science and Technology (KACST) , and many other international research organizations
  • Establishing a cell culture and molecular biology laboratory at Saad Research Center.

[April 2010] The Dubai Cord Blood and Research Centre, Dubai

  • Successful completion of training at Umbilical Cord-Blood and Stem Cell Technology

 [January 2007 – July 2008] National Guard Hospital, Pathology and Laboratory Medicine Department, Saudi Arabia

  • Medical Laboratory Technologist. Team leader and Quality Officer of Transfusion Medicine Services (TMS) Lab

 
Research title

Production of Red Blood Cells from Human Induced Pluripotent Stem Cells


Awards/Funding

  • King Abdullah Scholarships, Saudi Arabia
  • King Saud University, Saudi Arabia

 
Others

  •  Fluent Arabic and English speaker
Jan Marzinek

Nationality: Polish

E-mail: j.marzinek10@imperial.ac.uk
Office Tel:  +44 (0)7411 640 552
Supervisors:  Prof. Sakis Mantalaris, Prof. Stratos Pistikopoulos

Research Interests:

Molecular Dynamics:

  • Protein-ligand binding affinity predictions within all atom force field
  • Coarse-grain force field development and applications

Biography

Academic background
DateRole
 2010 - 2014  PhD in Chemical Engineering, Imperial College London, UK.
 2010 - 2014  Research Associate, Unilever R&D, Colworth Science Park, Bedford, UK.
 2005-2010  MSc in Chemical Engineering.
 
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Research title

Molecular Dynamics Modeling of Skin and Hair Proteins

Publications/Presentations

  • Marzinek JK, De Simone A, Frenkel D, Bond PJ, Harvey M, Noro MG, Lian G, Mantalaris A, Pistikopoulos EN. Coarse-Grained Force Field Development and Application for Interactions between Keratin Intermediate Filaments. To be submitted. 2014.
  • Marzinek JK, Bond PJ, Lian G, Zhao Y, Noro MG, Mantalaris A, Pistikopoulos EN, Han L. Free Energy Predictions of Ligand Binding to α-Helix within MD and Steered MD Simulations. Submitted. Journal of Chemical Information and Modeling, submitted in March 2014.
  • Zhao Y+,  Marzinek JK+, Bond PJ, Chen L, Qing Li, Mantalaris A, Pistikopoulos EN, Noro MG, Han L, Lian G. A Study on Ferrous Ion Binding to Keratin Using Isothermal Titration Calorimetry and Molecular Dynamics Simulation. Journal of Pharmaceutical Sciences, 2014, 103: 1224-1232 doi: 10.1002/jps.23895. +Equal contributors.
  • Marzinek JK, Zhao Y, Lian G, Mantalaris A, Pistikopoulos EN, Bond PJ, Noro MG, Han L, Chen L. Molecular and Thermodynamic Basis for EGCG-Keratin Interaction - Part I: Molecular Dynamics Simulations. AIChE Journal, 2013, 59: 4816–4823. doi: 10.1002/aic.14220. Manuscript published as “Best Presentation Paper”.
  • Zhao Y, Marzinek JK, Lian G, Mantalaris A, Pistikopoulos EN, Bond PJ, Noro M, Han L. Molecular and Thermodynamic Basis for EGCG - Keratin Interaction – Part II: Experimental Investigations. AIChE Journal, 2013. 59: 4824–4827. doi: 10.1002/aic.14221.

 
Awards/Funding

  • 2010-2013: MULTIMOD ITN, EC’s Seventh Framework Programme [FP7/2007-2013] under Grant Agreement N° 238013

 
Others

  • American Institute of Chemical Engineers (AICHE), 2012 Annual Meeting, Pittsburgh, USA. “Best Presentation” award in the session: “Industrial applications of Molecular Simulations” and invitation to the AICHE Journal as the “Best Paper”.  The abstract and presentation: Marzinek JK, Lian G, Mantalaris A, Pistikopoulos E.N. The Investigation of Green Tea Catechin Binding to Keratins by Molecular Dynamics and Experimental Validation.
Mauricio Zamorano Mosnaim

Nationality: Chilean
E-mail: m.zamorano11@imperial.ac.uk
Office: Room 509, Roderic Hill Building, Chemical Engineering Dept.
Office Tel: +44 (0) 2075941224
Supervisors: Prof. A. Mantalaris and Dr Xuebin Yang – Leeds University

Research Interests:

  • Bioreactor Technology for Stem Cell Bioprocessing.
  • Mesenchymal Stem Cells, Dental Pulp Stem Cells in vitro and in vivo for Dental Tissue Engineering.


Biography

Academic background
DateRole
 2012-present  PhD in Chemical Engineering, Imperial College London, UK.
 2009-2010  MSc in Food Technology, Universidad de Santiago de Chile Santiago, Chile.
 2003-2008  Bachelor Degree in Chemical Engineering, Universidad de Santiago de Chile Santiago, Chile.
 
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Research title

Expansion and Odontogenic Differentiation of a Dental Pulp Stem Cell Culture System to obtain a 3D Tooth Matrix in Vitro and in Vivo.


Publications/Presentations

  • Mahn, M. Zamorano, H. Barrientos, and A. Reyes, "Optimization of a process to obtain selenium-enriched freeze-dried broccoli with high antioxidant properties," LWT - Food Science and Technology, vol. 47, pp. 267-273, 2012.
  • M. Zamorano A. Reyes and A. Mahn, “Effect of Freeze-drying Conditions on Antioxidant Properties of Se-enriched Broccoli”,XXV Interamerican Congress of Chemical Engineering & XVIII Chilean Congress of Chemical Engineering, November 14-16, 2011, Santiago Chile.
  • Mahn, A. Reyes, M. Zamorano, W. Cifuentes, and M. Ismail, "Depletion of highly abundant proteins in blood plasma by hydrophobic interaction chromatography for proteomic analysis," Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, vol. 878, pp. 1038-1044, May 1 2010.
  • Mahn, M. C. Munoz, and M. J. Zamorano, "Discovery of Biomarkers That Reflect the Intake of Sodium Selenate by Nutritional Proteomics," Journal of Chromatographic Science, vol. 47, pp. 840-843, Oct 2009.
  • Mahn, M. Zamorano and W. Cifuentes, "Depletion of highly abundant proteins in blood plasma by hydrophobic interaction chromatography for proteomic analysis", COLACRO XII Latin American Congress of Chromatography and related Techniques, october 28- 30, 2008, Florianapolis, Brazil.
  • M. Zamorano and A. Mahn," Depletion of highly abundant proteins in blood plasma of rats by hydrophobic chromatography for proteomic analysis ", Poster for the LI reunión Anual Sociedad de Biología de Chile, Noviember 26-29,   2008, Pucón, Chile.


Teaching

  • 2009, 2010, and 2011: Transport Phenomena, 3rd year Chemical Engineering students, Universidad de Santiago de Chile
  • 2009: Fluid Mechanics, 4th year Chemical Engineering students, Universidad de Santiago de Chile
  • 2009: Heat and Mass Transfer 3rd year Biotech Engineering students, Universidad de Santiago de Chile
  • 2009: Multi-stage Mass transfer, 5th year Chemical Engineering students, Universidad de Santiago de Chile

 
Awards/Funding

  • 2012-: Becas-Chile Scholarship, Advanced Human Capital Program, National Commission for Scientific and Technological Research (CONICYT).
  • FONDECYT project no 1061154, Undergrad thesis funding.
  • FONDECYT project no 1100437, MSc thesis funding.
  • 2009-2010: Researcher funding, for MSc, Universidad de Santiago de Chile.

 
Others

  • 2010: Armando Quezada Scholarship, for Scientific and Technological Research, Universidad de Santiago de Chile
Maria Papathanasiou

Nationality: Greek
E-mail: maria.papathanasiou11@imperial.ac.uk
Office: C511 Roderic Hill Building, South Kensington Campus, Imperial College London
Office Tel: +44 207 594 6632
Supervisors:  Prof. Mantalaris and  Prof. E.N. Pistikopoulos

Research Interests:

  • Multi-parametric MPC
  • Process Control
  • Modeling & control of biomedical systems
  • Biopharmaceutical processes
  • FMCG processes.


Biography

Academic background
DateRole
 2012 - present PhD in Chemical Engineering, Imperial College London, UK.
 2011 - 2012 MSc in Advanced Chemical Engineering, Imperial College London
 2005 - 2010 5-year Chemical Engineering Diploma, National Technical University of Athens
 
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Publications/Presentations

  • Papathanasiou, M., Reineke, K., Taoukis, P. & Knorr, D. Impact of high pressure treatment on the available glucose of various starch types.  International Congress on Engineering and Food (iCEF), 2011 Athens, Greece.


Teaching

  • 2012-2013: Teaching Assistant for the course Advanced Process Optimization II, 4th year & MSc students, Chemical Engineering, Imperial College London
  • 2013-2014: Teaching Assistant for the course Advanced Process Optimization, 3rd, 4th year & MSc students, Chemical Engineering, Imperial College London


Awards/Funding

  • EU FP7 OPTICO Project

Others

  • iCEF 2011 Best Poster Presentation Award in Food Polymers Session for the poster: Papathanasiou, M., Reineke, K., Taoukis, P. & Knorr, D. Impact of high pressure treatment on the available glucose of various starch types

Contact details

Professor Sakis Mantalaris
Head of BSEL Group

Chemical Engineering Department

Tel: +44 (0)20 7594 5601

 

Email: 

a.mantalaris@imperial.ac.uk

 

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