We are developing real-time, Point-of-Care biosensor technologies to monitor antimicrobial concentrations within the body on microneedle platforms the size of a postage stamp and on a small handheld device like a blood glucose meter. When paired with closed-loop control and an infusion pump this technology allows us to correct an individual’s dose to an optimised set target to improve patient outcomes and reduce drivers of AMR. This is particularly important for some patient groups where optimising antimicrobial therapy is particularly challenging in (e.g. sepsis, obesity, multi-morbidity), or for resistant microorganisms.
We have also developed a microneedle biosensor to measure the well-known sepsis biomarker, lactate. This device will increase our ability to recognise and treat sepsis early, especially in patients at ward level where measuring lactate is difficult.
Our technological developments include:
- Aptameric and enzyme-based biosensor technology mounted on microneedle and Point of Care (PoC) platforms.
- Minimal and non-invasive sensing of antibiotics, antifungals and biomarkers.
- Artificial intelligence algorithms to correct antimicrobial dosing to achieve a set target.
Researchers
Professor Tony Gordon
Professor Tony Gordon
Chair in Anaesthesia and Critical Care
Professor Martin Wilkins
Professor Martin Wilkins
Vice Dean (Research) Faculty of Medicine
Professor Alison Holmes
Professor Alison Holmes
Professor of Infectious Diseases
Dr Danny O'Hare
Dr Danny O'Hare
Reader in Sensor Research
Dr Mark Gilchrist
Dr Mark Gilchrist
Honorary Senior Lecturer & Consultant Pharmacist Infectious Diseases
Professor Tony Cass
Professor Tony Cass
Professor of Chemistry
Professor Pantelis Georgiou
Professor Pantelis Georgiou
Chief Scientist / Professor in Biomedical Electronics
Dr Darius Armstrong-James
Dr Darius Armstrong-James
Reader in Infectious Diseases and Medical Mycology
Richard Wilson
Richard Wilson
Senior Healthcare Research Scientist
Dr Damien Ming
Dr Damien Ming
Clinical Research Fellow
Dr Pau Herrero-Viñas
Dr Pau Herrero-Viñas
Research Fellow
Tim Rawson
Tim Rawson
Clinical Trials Development Lead
Dr Alaa Riezk
Dr Alaa Riezk
Researcher
Dr Anand Shah
Dr Anand Shah
Honorary Clinical Senior Lecturer
Ashleigh Green
Ashleigh Green
Research Technician
Dr Bernard Hernandez Perez
Dr Bernard Hernandez Perez
Research Associate
Danny Chen
Danny Chen
Research Assistant
Dr David Freeman
Dr David Freeman
Research Associate
James McLeod
James McLeod
Research Postgraduate
Paul Arkell
Paul Arkell
Clinical Research Fellow
Dr Sally Gowers
Dr Sally Gowers
Research Associate
Saylee Jangam
Saylee Jangam
Research Postgraduate
Valentina Capizzuto
Valentina Capizzuto
Research Technician
William Bolton
William Bolton
Research Postgraduate