09:00-10-10 Physiology and disease (70 mins) – Chair Prof Luke Howard
Dr Tammie Bishop (Oxford) – Long talk
“HIF-2 in oxygen chemosensitivity and paragangliomas”
Dr Olena Rudyk (KCL) – Long talk
“Redox-Regulated Kinases in Pulmonary Hypertension”
Dr Tom Keeley (Oxford) – Long talk
“New mechanisms of oxygen sensing through N-terminal cysteine dioxygenation”
Coffee and tea break (20 mins)
10:30-11:40 Hypoxia Tools (70mins) – Chair Dr Rick Southworth
Dr Antoine Wallabregue (The Conway Group Oxford) – Long talk
“New fluorogenic probes to image different levels of hypoxia”
Dr Edward Waters. (KCL) – Short Talk
“Imaging mitochondrial membrane potentials in vivo with SPECT”
Dr Jie Shen (KCL) – Short talk
“Non-invasive imaging of hypoxia in cardiac hypertrophy using Positron Emission Tomography”
Dr Alexander Thompson (Imperial) – Short talk
“Longitudinal, non-invasive monitoring of hypoxia during tumour growth using diffuse reflectance spectroscopy”
11:40-13:00 Cancer session (70 mins) – Chair Dr Henry Robb
Dr Hannah Lawson (ICR London) – Long talk
“Hypoxia signaling as a therapeutic target in AML”
Dr Henry Robb (Imperial) – Long talk
“Volatile hypoxia signatures in oesophageal adenocarcinoma”
Dr Brian Ortmann (Newcastle) – Long Talk
“Defining the role of SET1B in the HIF transcriptional response and ccRCC progression”
Lunch and posters 13:00-14:00
14:00-15:10 Signalling/metabolism (70mins)
Dr Hudson Coates (Cambridge) – Long Talk
“Global protein stability screening uncovers targets of oxygen-regulated degradation
Dr Tekle Pauzaite (Cambridge) – Short talk
“Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response”
Dr Guine Grice (Cambridge) – Short talk
“Regulation of glutarylation and 2-oxoglutarate dependent dioxygenases”
Dr Andrew Murray (Cambridge) – Long Talk
“Metabolic adaptation to high-altitude hypoxia”
Break Coffee/Tea (20 mins)
15:30-16:40 Circulation and innate immune response (70 mins) – Prof Edwin Chilvers (Chair)
Prof Alexander Gourine (UCL) – Long Talk
“Mechanisms of cerebral blood flow control during hypoxia”
Dr Katharine Lodge (Imperial) – Long Talk
“Neutrophil phenotype in hypoxia”
Dr Charis Pericleous (Imperial) – Short talk
‘Modelling stroke in thrombotic antiphospholipid syndrome’
Dr Lida Kabir (LMS-MRC Imperial) – Short talk
‘Crosstalk between AMP-activated protein kinase and hypoxia signalling in the endothelium’